Lyon F, Dabbs T, O'Meara M
Department of Ophthalmology, St James's University Hospital, Leeds, UK.
Eye (Lond). 2008 May;22(5):684-6. doi: 10.1038/sj.eye.6702717. Epub 2007 Apr 6.
To report the use of ketamine sedation as an alternative anaesthetic method for babies undergoing treatment for retinopathy of prematurity (ROP).
All babies who underwent treatment for ROP over a 2-year period were included in this study. The babies preoperative weight, medical condition, and ventilation status was recorded. Data were collected on their ventilation status pre-, intra-, and postprocedure. Any change in their cardiac or respiratory status during or in the subsequent 3 days following the treatment was noted.
Eleven babies, 22 eyes, required treatment over this period. The procedure was well tolerated with only three babies having intraoperative complications, which all resolved spontaneously. Two babies had postoperative complications requiring additional ventilation. In no case was the procedure abandoned owing to anaesthetic complications.
The use of ketamine sedation allows the laser to be performed in a ward setting and avoids the potential risk of general anaesthesia and inter- and intra-hospital transfer. It has been found to produce few intra- or postoperative complications for the infant, while providing satisfactory conditions for the treatment of ROP.
报告氯胺酮镇静作为早产视网膜病变（ROP）患儿治疗的替代麻醉方法的应用情况。
本研究纳入了在2年期间接受ROP治疗的所有患儿。记录患儿术前体重、病情和通气状态。收集其术前、术中和术后的通气状态数据。记录治疗期间或治疗后3天内心脏或呼吸状态的任何变化。
在此期间，11名患儿的22只眼需要治疗。该操作耐受性良好，仅有3名患儿出现术中并发症，均自行缓解。2名患儿出现术后并发症，需要额外通气。无一例因麻醉并发症而放弃该操作。
使用氯胺酮镇静可在病房环境中进行激光治疗，避免全身麻醉及院际和院内转运的潜在风险。已发现该方法对婴儿产生的术中或术后并发症较少，同时为ROP治疗提供了满意的条件。
