Rotsztejn Helena, Trznadel-Budźko Ewa, Jesionek-Kupnicka Dorota
Section of Dermatology, Research Institute of the Polish Mother's Memorial Hospital, Rzgowska 281/284, 93-338 Łódź, Poland.
Arch Immunol Ther Exp (Warsz). 2007 Mar-Apr;55(2):127-30. doi: 10.1007/s00005-007-0016-8. Epub 2007 Mar 20.
Langerhans cells (LCs) are a very important part of the skin immune system.
Skin biopsies taken from 13 women after the removal of vulvar squamous cell carcinoma (SCC) who had not been treated earlier for any vulvar diseases were investigated. The control group consisted of 12 women who underwent a plastic surgical operation of the vulva region. Immunohistochemical staining was performed on formalin-fixed, paraffin-embedded tissues samples using antihuman CD1a antibody (NCL-CD1a-235, Novocastra).
This study showed a large decrease in LCs in vulvar SCC.
It is postulated that the reduction in the number of LCs may be one of the reasons for a higher tendency of carcinogenesis in the vulvar region. Their role as a main element of the skin immune system in the initiation of this process needs further investigation. It is possible that research on LCs in the skin will cast a new light on their role and even contribute to the prophylaxis and treatment of skin and mucosa carcinomas.
朗格汉斯细胞（LCs）是皮肤免疫系统的一个非常重要的组成部分。
对13名外阴鳞状细胞癌（SCC）切除术后且此前未接受过任何外阴疾病治疗的女性进行皮肤活检。对照组由12名接受外阴区域整形手术的女性组成。使用抗人CD1a抗体（NCL-CD1a-235，诺沃卡斯托）对福尔马林固定、石蜡包埋的组织样本进行免疫组织化学染色。
本研究显示外阴SCC中LCs大量减少。
据推测，LCs数量的减少可能是外阴区域致癌倾向较高的原因之一。它们作为皮肤免疫系统的主要元素在这一过程起始中的作用需要进一步研究。对皮肤中LCs的研究有可能为其作用带来新的认识，甚至有助于皮肤和黏膜癌的预防和治疗。
