Gómez Marisa I, Prince Alice
Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
Curr Opin Pharmacol. 2007 Jun;7(3):244-51. doi: 10.1016/j.coph.2006.12.005. Epub 2007 Apr 5.
Pseudomonas aeruginosa is an opportunistic pathogen that significantly contributes to morbidity and mortality in patients with cystic fibrosis. Defective mucociliary clearance associated with the absence of the functional cystic fibrosis transmembrane conductance regulator in airway epithelium plays a critical role in the initial colonization of this pathogen. P. aeruginosa, while initiating a profound inflammatory response, employs multiple mechanisms to evade immune clearance. The capacity to grow in biofilms and the selection of mutants with a mucoid phenotype are major adaptations that allow its persistence in the airways.
铜绿假单胞菌是一种机会致病菌，在囊性纤维化患者的发病和死亡中起重要作用。气道上皮中功能性囊性纤维化跨膜传导调节因子缺失导致的黏液纤毛清除功能缺陷在该病原体的初始定植中起关键作用。铜绿假单胞菌在引发强烈炎症反应的同时，采用多种机制逃避免疫清除。在生物膜中生长的能力以及黏液样表型突变体的选择是使其在气道中持续存在的主要适应性变化。
