Key Laboratory of Medical Molecular Virology (Ministry of Education (MOE)/National Health Commission (NHC)/Chinese Academy of Medical Sciences (CAMS)), School of Basic Medical Science, Fudan University, Shanghai, China.
Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
Front Cell Infect Microbiol. 2022 Jul 6;12:926758. doi: 10.3389/fcimb.2022.926758. eCollection 2022.
is an opportunistic pathogen causing nosocomial infections in severely ill and immunocompromised patients. Ubiquitously disseminated in the environment, especially in hospitals, it has become a major threat to human health due to the constant emergence of drug-resistant strains. Multiple resistance mechanisms are exploited by , which usually result in chronic infections difficult to eradicate. Diverse virulence factors responsible for bacterial adhesion and colonization, host immune suppression, and immune escape, play important roles in the pathogenic process of . As such, antivirulence treatment that aims at reducing virulence while sparing the bacterium for its eventual elimination by the immune system, or combination therapies, has significant advantages over traditional antibiotic therapy, as the former imposes minimal selective pressure on , thus less likely to induce drug resistance. In this review, we will discuss the virulence factors of , their pathogenic roles, and recent advances in antivirulence drug discovery for the treatment of infections.
是一种机会性病原体，可导致重病和免疫功能低下患者发生医院获得性感染。它广泛存在于环境中，尤其是在医院中，由于不断出现耐药菌株，已成为人类健康的主要威胁。通过多种耐药机制，通常会导致慢性感染难以根除。多种毒力因子负责细菌黏附和定植、宿主免疫抑制和免疫逃逸，在的致病过程中发挥重要作用。因此，与传统抗生素治疗相比，以降低毒力而不损害细菌，从而最终通过免疫系统清除细菌为目标的抗病毒治疗，或联合治疗具有显著优势，因为前者对施加的选择性压力最小，因此不太可能诱导耐药性。在这篇综述中，我们将讨论的毒力因子、它们的致病作用以及用于治疗感染的抗病毒药物发现的最新进展。
