Nordby G, Norum K R
Scand J Clin Lab Invest. 1975 Nov;35(7):677-82.
Desmosterol and beta-sitosterol were esterified when incubated with normal human plasma. The initial rate of demosterol esterification was 1.7 times faster, and that of beta-sitosterol 0.4 times slower, than the esterification rate of cholesterol. These ratios were found to be almost the same when plasma from different normal individuals was tested. Plasma from a patient with familial lecithin:cholesterol acyltransferase deficiency did not esterify any of the sterols. The esterification of desmosterol and beta-sitosterol was considerably slower in normal plasma in which in vitro cholesterol esterification previously had taken place. The different esterification rates could not be explained by a different affinity of the plasma lipoproteins for the sterols tested. Cholecalciferol added to normal plasma did not become esterified.
将去氢胆甾醇和β-谷甾醇与正常人血浆一起温育时，它们会被酯化。去氢胆甾醇的初始酯化速率比胆固醇的酯化速率快1.7倍，而β-谷甾醇的初始酯化速率比胆固醇的酯化速率慢0.4倍。当检测来自不同正常个体的血浆时，发现这些比率几乎相同。患有家族性卵磷脂：胆固醇酰基转移酶缺乏症患者的血浆不能使任何一种甾醇酯化。在先前已发生体外胆固醇酯化的正常血浆中，去氢胆甾醇和β-谷甾醇的酯化要慢得多。血浆脂蛋白对所检测甾醇的不同亲和力无法解释不同的酯化速率。添加到正常血浆中的胆钙化醇不会被酯化。
