Berlie H C, Petit J C, David H L
Laboratoire de Bactériologie-Virologie, Faculté de Médecine, Hôpital Saint Antoine, Paris, France.
Zentralbl Bakteriol. 1991 Aug;275(3):351-7. doi: 10.1016/s0934-8840(11)80299-9.
At a predetermined specificity of 100.0%, the sensitivity of ELISA using the PGL-Tb1 and SL-IV antigens and IgG assays was 35.0% for the diagnosis of tuberculosis in AIDS patients (44.1% when tuberculosis was diagnosed before AIDS, 21.7% when AIDS was diagnosed before tuberculosis). Serial assays in sera collected from 11 AIDS patients before tuberculosis was diagnosed indicated that significant antibody titres were detected 10 months before the onset of clinical tuberculosis. Consequently, it was proposed that serodiagnosis using the glycolipid specific antigens should help in deciding on preventive antituberculosis treatment in these patients.
在预定特异性为100.0%时，使用PGL-Tb1和SL-IV抗原及IgG检测的ELISA法诊断艾滋病患者结核病的敏感性为35.0%（结核病在艾滋病之前诊断时为44.1%，艾滋病在结核病之前诊断时为21.7%）。对11例艾滋病患者在结核病诊断前采集的血清进行系列检测表明，在临床结核病发病前10个月就检测到了显著的抗体滴度。因此，有人提出使用糖脂特异性抗原进行血清学诊断应有助于确定对这些患者进行预防性抗结核治疗。
