McIlwaine Maggie
School of Rehabilitation Sciences, University of British Columbia and Professional Practice Leader, Department of Physiotherapy, BC Children's Hospital, Vancouver, Canada.
Paediatr Respir Rev. 2007 Mar;8(1):8-16. doi: 10.1016/j.prrv.2007.02.013. Epub 2007 Mar 26.
Chest physiotherapy in the form of airway clearance techniques and exercise has played an important role in the treatment of cystic fibrosis. Until the 1990s the primary airway clearance technique used was postural drainage combined with percussion and vibration (PD&P). It was introduced into the treatment of CF with little evidence to support its efficacy and once established, it has been difficult ethically to perform a study comparing PD&P to no treatment. A common question, yet unanswered is when should it be commenced, especially for the newly diagnosed asymptomatic CF patient? Recently, the technique of PD&P has been modified to include only non-dependant head-down positioning due to the detrimental effects of placing a person in a Trendelenburg position. In the 1990s other airway clearance techniques gained popularity, in that they could be performed independently, in a sitting position and avoided many of the detrimental effects of PD&P. These techniques include the Active cycle of breathing technique, formally called the Forced expiration technique and Autogenic drainage. Both these breathing techniques aim at using expiratory airflow to mobilize secretions up the airways and incorporate breathing strategies to assist in the homogeneity of ventilation. Studies suggest that both these techniques are as effective if not more effective than as PD&P and offer many advantages over PD&P. It has been suggested that exercise can be used as an airway clearance technique; however the literature does not support this. Rather, when exercise is used in addition to an airway clearance technique there is enhanced secretion removal and an overall benefit to the patient. Further research needs to be directed at assessing the effects of an airway clearance technique on the individual patient using appropriate outcome measures.
以气道清除技术和运动为形式的胸部物理治疗在囊性纤维化的治疗中发挥了重要作用。直到20世纪90年代,使用的主要气道清除技术是体位引流联合叩击和振动(PD&P)。它被引入到CF治疗中时几乎没有证据支持其疗效,而且一旦确立,从伦理角度很难开展一项将PD&P与不治疗进行比较的研究。一个常见但尚未得到解答的问题是,尤其是对于新诊断的无症状CF患者,应该何时开始进行这种治疗?最近,由于将患者置于头低脚高位会产生有害影响,PD&P技术已被修改为仅包括非依赖头低脚高位。在20世纪90年代,其他气道清除技术开始流行,因为它们可以独立进行,患者处于坐姿,并且避免了PD&P的许多有害影响。这些技术包括主动呼吸循环技术(以前称为用力呼气技术)和自主引流。这两种呼吸技术都旨在利用呼气气流将分泌物向上推送至气道,并采用呼吸策略来辅助通气的均匀性。研究表明,这两种技术即使不比PD&P更有效,也与PD&P一样有效,并且相对于PD&P有许多优势。有人认为运动可以用作气道清除技术;然而文献并不支持这一点。相反,当运动与气道清除技术一起使用时,分泌物清除会增强,对患者有总体益处。需要进一步开展研究,使用适当的结果指标来评估气道清除技术对个体患者的影响。