Kluft J, Beker L, Castagnino M, Gaiser J, Chaney H, Fink R J
Department of Pulmonary Medicine, Children's National Medical Center, Washington, DC 20010, USA.
Pediatr Pulmonol. 1996 Oct;22(4):271-4. doi: 10.1002/(SICI)1099-0496(199610)22:4<271::AID-PPUL7>3.0.CO;2-P.
We compared standard chest physical therapy and postural drainage (CPT/PD) with a new airway clearance therapy called high-frequency chest wall oscillation (HFCWO) in a group of stable cystic fibrosis (CF) patients. In this crossover trial, 29 CF patients (15 males, 14 females), aged 7-47 years that met the inclusion criteria were randomly assigned to alternate CPT/PD and HFCWO, on a daily basis, over a 4 day period. Each patient received 2 days of each form of therapy; treatment frequency and the length of treatment were the same for both techniques. Expectorated secretions were collected during each 30 minute therapy session and for 15 minutes following treatment. The wet and dry weights of collected secretions were determined gravimetrically, and the therapy methods were compared. Significantly more sputum was expectorated during HFCWO than during CPT/PD as determined by both the wet (P < 0.001) and the dry (P < 0.01) measurements. This study suggests that HFCWO is at least as effective as manual CPT/PD in clearing secretions from the airways in patients with cystic fibrosis.
我们在一组稳定期囊性纤维化（CF）患者中，将标准胸部物理治疗和体位引流（CPT/PD）与一种名为高频胸壁振荡（HFCWO）的新气道清除疗法进行了比较。在这项交叉试验中，29名符合纳入标准、年龄在7至47岁的CF患者（15名男性，14名女性）被随机分配，在4天的时间里每天交替接受CPT/PD和HFCWO治疗。每位患者每种治疗方式各接受2天；两种技术的治疗频率和治疗时长相同。在每次30分钟的治疗过程中以及治疗后15分钟收集咳出的分泌物。通过重量法测定收集分泌物的湿重和干重，并对治疗方法进行比较。通过湿重（P < 0.001）和干重（P < 0.01）测量均发现，HFCWO期间咳出的痰液明显多于CPT/PD期间。这项研究表明，在清除囊性纤维化患者气道分泌物方面，HFCWO至少与手动CPT/PD一样有效。
