Zhang Yapeng, Zhu Tianjiao, Fang Yuchun, Liu Hongbing, Gu Qianqun, Zhu Weiming
Key Laboratory of Marine Drugs, Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao, PR China.
J Antibiot (Tokyo). 2007 Feb;60(2):153-7. doi: 10.1038/ja.2007.15.
Two new secondary metabolites, carbonarones A (1) and B (2), were obtained from the culture of the marine-derived fungus Aspergillus carbonarius isolated from the marine sediment collected at Weizhou island of China. Based on ESIMS, 1D and 2D NMR data, and the X-ray crystallographic analysis, their structures were elucidated as 6-benzyl-4-oxo-4H-pyran-3-carboxamide and 6-benzyl-4-hydroxy-2-oxo-1, 2-dihydropyridine-3-carbaldehyde, respectively. 1 and 2 showed moderate cytotoxicity against K562 cells with IC(50) values of 56.0 and 27.8 mug/ml, respectively.
从中国涠洲岛采集的海洋沉积物中分离得到的海洋来源真菌炭黑曲霉的培养物中，获得了两种新的次生代谢产物，即碳萘醌A（1）和B（2）。基于电喷雾离子化质谱（ESIMS）、一维和二维核磁共振（NMR）数据以及X射线晶体学分析，它们的结构分别被鉴定为6-苄基-4-氧代-4H-吡喃-3-甲酰胺和6-苄基-4-羟基-2-氧代-1,2-二氢吡啶-3-甲醛。化合物1和2对K562细胞显示出中等细胞毒性，其半数抑制浓度（IC50）值分别为56.0和27.8μg/ml。
