海洋细菌和真菌中的生物活性化合物。
Bioactive compounds from marine bacteria and fungi.
机构信息
Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine Universitaet Duesseldorf, Germany.
出版信息
Microb Biotechnol. 2010 Sep;3(5):544-63. doi: 10.1111/j.1751-7915.2010.00179.x. Epub 2010 May 23.
Abstract
Marine bacteria and fungi are of considerable importance as new promising sources of a huge number of biologically active products. Some of these marine species live in a stressful habitat, under cold, lightless and high pressure conditions. Surprisingly, a large number of species with high diversity survive under such conditions and produce fascinating and structurally complex natural products. Up till now, only a small number of microorganisms have been investigated for bioactive metabolites, yet a huge number of active substances with some of them featuring unique structural skeletons have been isolated. This review covers new biologically active natural products published recently (2007-09) and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action.
摘要
海洋细菌和真菌是非常重要的新的有前途的生物活性产物来源。这些海洋物种中的一些生活在恶劣的环境中，处于寒冷、无光和高压的条件下。令人惊讶的是，大量具有高度多样性的物种在这种条件下生存，并产生迷人的、结构复杂的天然产物。到目前为止，只有少数微生物被用于生物活性代谢物的研究，但已经分离出了大量具有独特结构骨架的活性物质。本综述涵盖了最近（2007-09 年）发表的具有生物活性的新型天然产物，并强调了海洋微生物的化学潜力，重点是生物活性产物及其作用机制。
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