Xie Yunying, Chen Ruxian, Si Shuyi, Sun Chenghang, Xu Hongzhang
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Tiantanxili, Beijing, PR China.
J Antibiot (Tokyo). 2007 Feb;60(2):158-61. doi: 10.1038/ja.2007.16.
A new nucleosidyl-peptide antibiotic, sansanmycin, was isolated from an unidentified Streptomyces sp SS. The structure of sansanmycin was elucidated by analyses of its alkaline hydrolysate and spectroscopic analyses. Sansanmycin exhibits antibacterial activity against Mycobacterium tuberculosis H(37)Ra and Pseudomonas aeruginosa with MIC values of 10 and 12.5 mug/ml, respectively.
一种新的核苷基肽类抗生素——三三霉素，是从一株未鉴定的链霉菌属SS菌株中分离得到的。通过对其碱性水解产物的分析和光谱分析确定了三三霉素的结构。三三霉素对结核分枝杆菌H(37)Ra和铜绿假单胞菌具有抗菌活性，其最低抑菌浓度（MIC）值分别为10和12.5微克/毫升。
