三三霉素B和C，三三霉素的新组分。
Sansanmycins B and C, new components of sansanmycins.
作者信息
Xie Yunying, Xu Hongzhang, Si Shuyi, Sun Chenghang, Chen Ruxian
机构信息
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, China.
出版信息
J Antibiot (Tokyo). 2008 Apr;61(4):237-40. doi: 10.1038/ja.2008.34.
Two new antibiotics, sansanmycins B and C, were isolated from Streptomyces sp. SS. Their structures were elucidated by extensive 1D and 2D NMR and MS spectral analyses. Sansanmycins B and C exhibited inhibitory activity against our test strain of Pseudomonas aeruginosa with MIC values of 8.0 and 16 microg/ml, respectively. Sansanmycin B also exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant Mycobacterium tuberculosis, with the MIC values ranging from 8.0 to 20 microg/ml.
从链霉菌属SS中分离出了两种新抗生素，即三三霉素B和三三霉素C。通过广泛的一维和二维核磁共振及质谱分析确定了它们的结构。三三霉素B和三三霉素C对我们测试的铜绿假单胞菌菌株具有抑制活性，其最低抑菌浓度（MIC）值分别为8.0和16微克/毫升。三三霉素B对结核分枝杆菌H37Rv和耐多药结核分枝杆菌也具有抑制活性，其MIC值在8.0至20微克/毫升之间。
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