Bosu W T, Waelchli-Suter R O
Can Vet J. 1983 Dec;24(12):371-4.
Eleven mature Beagle bitches were artificially inseminated and then used to determine the effects of ethinylestradiol or danazol on nidation, embryo survival and maintenance of pregnancy. The dogs were grouped so that three were kept as controls, four others were treated with ethinylestradiol and the remaining four were treated with danazol. The compounds were administered orally at varying intervals after insemination. The effects of the compounds were deduced from the condition of the ovaries and uterus examined at laparotomy, and the results of whelping. Ethinylestradiol had minimal effect on embryo development and implantation. Three of four bitches treated with ethinylestradiol whelped. Similarly, danazol treatment had little or no effect on embryonic survival and implantation. It is concluded that, ethinylestradiol or danazol at the dosages and schedules used in this study did not significantly interfere with embryonic survival or implantation in pregnant Beagle bitches.
11只成年比格母犬接受人工授精，然后用于确定炔雌醇或达那唑对着床、胚胎存活和维持妊娠的影响。将这些犬分组，3只作为对照，另外4只接受炔雌醇治疗，其余4只接受达那唑治疗。在授精后的不同时间间隔口服给予这些化合物。根据剖腹探查时检查的卵巢和子宫状况以及分娩结果推断化合物的作用。炔雌醇对胚胎发育和着床的影响最小。接受炔雌醇治疗的4只母犬中有3只分娩。同样，达那唑治疗对胚胎存活和着床几乎没有影响。得出的结论是，本研究中使用的剂量和给药方案的炔雌醇或达那唑不会显著干扰怀孕比格母犬的胚胎存活或着床。
