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猫暗色丝孢霉病:酮康唑和5-氟胞嘧啶治疗

Feline phaeohyphomycosis: treatment with ketaconazole and 5-fluorocytosine.

作者信息

Pukay B P, Dion W M

出版信息

Can Vet J. 1984 Mar;25(3):130-4.

PMID:17422372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1790492/
Abstract

Two cats with phaeohyphomycosis, one infected with Phialophora verrucosa and the other with Exophiala jeanselmei, were treated with ketaconazole alone and in combination with 5-fluorocytosine after recurrence of the infections following surgical excision. The drugs were given orally at various doses and for various lengths of time, but were ineffective. Hepatocellular damage occurred in one cat.

摘要

两只患有暗色丝孢霉病的猫,一只感染疣状瓶霉,另一只感染甄氏外瓶霉,在手术切除感染灶复发后,分别单独使用酮康唑以及联合使用5-氟胞嘧啶进行治疗。药物以不同剂量和不同时长口服给药,但均无效。其中一只猫出现了肝细胞损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a8/1790492/c69d6cf65bc8/canvetj00256-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a8/1790492/b498b4d44c56/canvetj00256-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a8/1790492/b0f9cfc76d38/canvetj00256-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a8/1790492/c69d6cf65bc8/canvetj00256-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a8/1790492/b498b4d44c56/canvetj00256-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a8/1790492/b0f9cfc76d38/canvetj00256-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a8/1790492/c69d6cf65bc8/canvetj00256-0022-a.jpg

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本文引用的文献

1
Feline Cutaneous Phaeohyphomycosis Caused by Phialophora verrucosa.疣状瓶霉引起的猫皮肤暗色丝孢霉病
Can Vet J. 1982 Feb;23(2):48-9.
2
Pheomycotic cyst in an immunosuppressed host.
J Am Acad Dermatol. 1981 Oct;5(4):423-7. doi: 10.1016/s0190-9622(81)80003-5.
3
Phaeohyphomycosis and cryptococcosis in a cat.一只猫的暗色丝孢霉病和隐球菌病。
Vet Pathol. 1982 Sep;19(5):554-6. doi: 10.1177/030098588201900511.
Med Mycol Case Rep. 2019 Dec 24;27:32-35. doi: 10.1016/j.mmcr.2019.12.008. eCollection 2020 Mar.
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Phaeohyphomycoses, emerging opportunistic diseases in animals.暗色丝孢霉病,动物中新兴的机会性疾病。
Clin Microbiol Rev. 2013 Jan;26(1):19-35. doi: 10.1128/CMR.00065-12.
5
Invasive mould infections of the naso-orbital region of cats: a case involving Aspergillus fumigatus and an aetiological review.猫鼻眶区域的侵袭性霉菌感染:一例涉及烟曲霉的病例及病因学综述。
J Feline Med Surg. 2010 Sep;12(9):714-23. doi: 10.1016/j.jfms.2010.07.015.
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Treatment of canine blastomycosis with ketoconazole.
J Am Vet Med Assoc. 1983 Jan 15;182(2):156-7.
5
Disseminated histoplasmosis in a cat: successful treatment with ketoconazole.
J Am Vet Med Assoc. 1982 Oct 15;181(8):817-20.
6
Cutaneous phaeohyphomycosis of the sole caused by Exophiala jeanselmei and its susceptibility to amphotericin B, 5-FC and ketoconazole.由甄氏外瓶霉引起的足底皮肤暗色丝孢霉病及其对两性霉素B、5-氟胞嘧啶和酮康唑的敏感性
Mycopathologia. 1982 Aug 20;79(2):101-4. doi: 10.1007/BF00468086.
7
Susceptibility of dermatiaceous fungi to amphotericin B, miconazole, ketoconazole, flucytosine and rifampin alone and in combination.皮肤真菌对两性霉素B、咪康唑、酮康唑、氟胞嘧啶和利福平单独及联合使用的敏感性。
Sabouraudia. 1982 Jun;20(2):109-13. doi: 10.1080/00362178285380181.
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Phaeohyphomycosis caused by Drechslera spicifera in a cat.猫感染尖孢德氏霉引起的暗色丝孢霉病。
J Am Vet Med Assoc. 1975 Jan 15;166(2):150-4.
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Phaeomycotic granuloma in a cat.猫的暗色丝孢霉病肉芽肿
Vet Pathol. 1978 Jul;15(4):559-61. doi: 10.1177/030098587801500415.