Kettlewell P, McGinnis M R, Wilkinson G T
Department of Veterinary Pathology, University of Queensland, St. Lucia, Brisbane, Australia.
J Med Vet Mycol. 1989;27(4):257-64.
The dematiaceous fungus Exophiala spinifera was isolated from a cutaneous lesion on the paw of a male domestic shorthair cat and from the nasal exudate and abscess contents from a female domestic shorthair cat. Treatment with ketoconazole (10 mg kg-1 daily) resulted in improvement in the first cat but unfortunately this animal was subsequently lost to follow-up. The second cat was treated initially by the same regimen without apparent benefit. The dose of ketoconazole was subsequently increased but finally had to be discontinued when the cat developed signs of hepatotoxicity. At this stage treatment with flucytosine (150 mg kg-1 daily) was commenced. The cat improved and cultures of nasal exudate performed 8 and 16 weeks after initiation of 5-fluorocytosine therapy were negative for E. spinifera. However, the condition recurred with granulomatous tissue appearing in each nostril and abscess formation with subsequent rupture occurring on the bridge of the nose when therapy was withdrawn. These two cases constitute the first report of E. spinifera infection in animals and of this fungal infection in Australia.
从一只雄性家养短毛猫爪子上的皮肤损伤处以及一只雌性家养短毛猫的鼻分泌物和脓肿内容物中分离出了暗色丝孢菌棘状外瓶霉。用酮康唑（每日10毫克/千克）治疗使第一只猫的病情有所改善，但不幸的是，这只动物随后失访。第二只猫最初采用相同的治疗方案，但未见明显效果。随后增加了酮康唑的剂量，但最终在猫出现肝毒性迹象时不得不停药。此时开始用氟胞嘧啶（每日150毫克/千克）治疗。这只猫的病情有所改善，在开始5-氟胞嘧啶治疗8周和16周后进行的鼻分泌物培养未发现棘状外瓶霉。然而，当治疗停止后，病情复发，每个鼻孔出现肉芽肿组织，并形成脓肿，随后鼻梁处发生破溃。这两例病例是动物感染棘状外瓶霉以及澳大利亚首次报道这种真菌感染的病例。
