Cribb A E, Burgener D C, Reimann K A
Can Vet J. 1988 Aug;29(8):654-7.
Seven icteric dogs were determined to have bile duct obstruction secondary to chronic pancreatitis. All dogs had histories of intermittent vomiting and diarrhea. Alkaline phosphatase and alanine aminotransferase activities and total bilirubin concentrations were markedly elevated. Diagnosis was based on exploratory laparotomy and histological examination. Each dog had a 3 to 10 cm mass in the body of the pancreas and obstruction of the common bile duct. Three dogs treated with pancreatectomy, gastrojejunostomy, and cholecystojejunostomy died within five weeks. Three dogs treated with conservative surgical procedures were alive at 8, 16, and 26 months postoperatively. One dog was euthanized because of suspected neoplasia. Hepatic enzyme activity and bilirubin levels decreased markedly in the surviving dogs. Histological examination of the pancreatic masses indicated chronic pancreatitis. Hepatic biopsies revealed evidence of cholestasis. Chronic pancreatitis should be included in the differential diagnoses of icterus, bile duct obstruction, and masses in the pancreas.
七只黄疸犬被诊断为继发于慢性胰腺炎的胆管阻塞。所有犬均有间歇性呕吐和腹泻病史。碱性磷酸酶、丙氨酸转氨酶活性及总胆红素浓度均显著升高。诊断基于剖腹探查术和组织学检查。每只犬的胰腺体部有一个3至10厘米的肿块，胆总管阻塞。三只接受胰切除术、胃空肠吻合术和胆囊空肠吻合术治疗的犬在五周内死亡。三只接受保守手术治疗的犬在术后8、16和26个月存活。一只犬因疑似肿瘤而实施安乐死。存活犬的肝酶活性和胆红素水平显著下降。胰腺肿块的组织学检查显示为慢性胰腺炎。肝活检显示有胆汁淤积的证据。黄疸、胆管阻塞和胰腺肿块的鉴别诊断应包括慢性胰腺炎。
