Strombeck D R, Wheeldon E, Harrold D
Am J Vet Res. 1984 Jan;45(1):131-6.
A model of chronic pancreatitis was developed and characterized in the dog. Pancreatitis was produced by infusion of oleic acid through a cannula in the accessory pancreatic duct. Biochemical changes included early and marked increases in serum amylase and lipase activities which returned to base line within 3 weeks, at which time the dogs were clinically normal. In dogs euthanatized within 2 weeks, pathologic changes included massive necrosis and hemorrhage, cystic spaces filled with fluid, and abscesses. Histologic features revealed acute exudative pancreatitis with pancreatic atrophy and fibrosis. In dogs killed between weeks 3 to 12, changes included: marked atrophy with remaining acini surrounded by remnants consisting of collapsed stroma, blood vessels, and pancreatic ducts; marked coarse fibrosis with scattered inflammatory cells and occasional acinar tissue; and large irregular pseudocysts.
在犬类中建立并表征了一种慢性胰腺炎模型。通过辅助胰管插管注入油酸来诱发胰腺炎。生化变化包括血清淀粉酶和脂肪酶活性早期显著升高，在3周内恢复至基线水平，此时犬在临床上表现正常。在2周内实施安乐死的犬中，病理变化包括大量坏死和出血、充满液体的囊性间隙以及脓肿。组织学特征显示为伴有胰腺萎缩和纤维化的急性渗出性胰腺炎。在第3至12周处死的犬中，变化包括：显著萎缩，剩余腺泡被由塌陷的间质、血管和胰管组成的残余物包围；显著的粗大纤维化，伴有散在的炎症细胞和偶尔的腺泡组织；以及大的不规则假性囊肿。
