Reed J H
Can Vet J. 1988 Sep;29(9):705-8.
Tetracycline, metronidazole, and chlorhexidine have been tested for their effectiveness in the treatment of periodontitis in dogs under experimental conditions. Tetracycline has been effective in reducing bone resorption in dogs with periodontitis when used in the long-term. When used for short times, it can result in reduction of the numbers of microorganisms that are associated with disease. Tetracycline can inhibit the activity of mammalian collagenase thought responsible for the destruction of alveolar bone and it may be capable of inhibiting the adherence of microorganisms and thus preventing infection. In some experiments, metronidazole was more effective than tetracycline in eliminating spirochetes from the periodontal flora, and it has been found effective in preventing the inflammation and the development of the bacterial flora usually associated with the natural accumulation of plaque. Chlorhexidine (0.2% aqueous solution) has been found effective in preventing the normal progression of periodontal disease when used as a spray for the long-term treatment of dogs. It could prove to be as effective as brushing for the long-term control of periodontitis in the dog. Limited information is available on the use of clindamycin, spiramycin, and vancomycin.
在实验条件下,已对四环素、甲硝唑和洗必泰治疗犬牙周炎的有效性进行了测试。长期使用时,四环素对减少患有牙周炎的犬的骨吸收有效。短期使用时,它可导致与疾病相关的微生物数量减少。四环素可抑制被认为是造成牙槽骨破坏的哺乳动物胶原酶的活性,并且它可能能够抑制微生物的黏附从而预防感染。在一些实验中,甲硝唑在从牙周菌群中清除螺旋体方面比四环素更有效,并且已发现它在预防通常与牙菌斑自然积聚相关的炎症和细菌菌群发展方面有效。已发现洗必泰(0.2%水溶液)作为喷雾剂长期治疗犬时,在预防牙周疾病的正常进展方面有效。它可能被证明在长期控制犬牙周炎方面与刷牙一样有效。关于克林霉素、螺旋霉素和万古霉素的使用,可获得的信息有限。