Magnusson I
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, USA.
Compend Contin Educ Dent. 1998 Oct;19(10):953-6; 958, 960 passim quiz 966.
Periodontitis is a result of an infection with specific pathogenic microorganisms. Thus, the local delivery of antimicrobials has been investigated as a possible method for controlling this infection and treating periodontal disease. A number of antimicrobial agents have been studied both as adjunctive therapies with scaling and root planing and as stand-alone chemotherapies. These agents have been administered in irrigation solutions and as single-dose formulations, but with little long-term efficacy in the treatment of periodontitis. Recent investigations have focused on the delivery of antimicrobials in sustained-release formulations designed to maintain effective concentrations of drug within the periodontal pocket. This article provides an overview of the development of the use of locally delivered antimicrobials in periodontal therapy and the current state-of-the-art of the technique.
牙周炎是特定致病微生物感染的结果。因此，抗菌剂的局部递送已被作为控制这种感染和治疗牙周疾病的一种可能方法进行研究。许多抗菌剂已作为龈下刮治和根面平整的辅助疗法以及单独的化学疗法进行了研究。这些药剂已被用于冲洗液中并制成单剂量制剂，但在治疗牙周炎方面长期疗效甚微。最近的研究集中在将抗菌剂制成缓释制剂，旨在在牙周袋内维持有效的药物浓度。本文概述了局部递送抗菌剂在牙周治疗中的应用发展情况以及该技术的当前发展水平。
