Gordon J M, Walker C B, Murphy J C, Goodson J M, Socransky S S
J Clin Periodontol. 1981 Apr;8(2):117-21. doi: 10.1111/j.1600-051x.1981.tb02351.x.
The concentration of tetracycline in gingival fluid was measured following the oral administration of single doses of 250 or 500 mg. Six volunteers received a single dose of either 250 mg or 500 mg of tetracycline and gingival fluid was sampled at 15-min intervals during the first 2 h, 30-min intervals for the following 2 h and at hours 5, 6 and 7. Four volunteers were given a single dose of either 250 mg or 500 mg and were sampled every hour for 24 h. Gingival fluid was sampled using an intracrevicular technique from four gingival sites and blood was obtained by finger puncture. The concentration of tetracycline in gingival fluid peaked at 3 1/2-7 h achieving average levels typically in the range of 5-12 micrograms/ml. Blood levels peaked at 3-4 h and reached values between 1.0 to 2.6 micrograms/ml. Tetracycline was detectable in gingival fluid at least 19 h after a single dose but rarely was detectable at 24 h. The results demonstrated that tetracycline in the gingival fluid was typically 2-10 times blood levels after a single dose.
单次口服250毫克或500毫克剂量的四环素后，测量牙龈液中四环素的浓度。六名志愿者分别单次服用250毫克或500毫克四环素，在最初2小时内每隔15分钟采集一次牙龈液样本，接下来的2小时内每隔30分钟采集一次，在第5、6和7小时也进行采集。四名志愿者分别单次服用250毫克或500毫克，并在24小时内每小时采集一次样本。使用龈沟内技术从四个牙龈部位采集牙龈液样本，通过手指穿刺获取血液样本。牙龈液中四环素的浓度在3.5至7小时达到峰值，平均水平通常在5至12微克/毫升范围内。血液浓度在3至4小时达到峰值，数值在1.0至2.6微克/毫升之间。单次给药后至少19小时在牙龈液中可检测到四环素，但在24小时时很少能检测到。结果表明，单次给药后牙龈液中的四环素浓度通常是血液浓度的2至10倍。
