Jacobs R M, Lumsden J H, Grift E
Can Vet J. 1992 Sep;33(9):605-8.
Interferences caused by bilirubin, hemolysis, and lipemia on 25 clinical chemistry analytes in bovine, canine, equine, and feline sera were studied using the Coulter Dacos and commercial reagents. We present the data as "interferograms", which show the anticipated percent change in serum analyte activity or concentration with varying concentrations of bilirubin, hemoglobin, or lipid. Obvious species differences in response to at least one added interfering substance were found for alanine aminotransferase, aspartate aminotransferase, cholesterol, creatine kinase, globulin, total protein, and urea. The remaining analytes were affected in a linear or complex dose-response relationship or were only affected at the highest concentrations of interfering substances. These data will be useful in aiding interpretation of laboratory test results when common interferences are present in the serum.
使用库尔特Dacos和商用试剂，研究了胆红素、溶血和脂血对牛、犬、马和猫血清中25种临床化学分析物的干扰。我们将数据呈现为“干扰图”，其显示了随着胆红素、血红蛋白或脂质浓度的变化，血清分析物活性或浓度的预期百分比变化。对于丙氨酸氨基转移酶、天冬氨酸氨基转移酶、胆固醇、肌酸激酶、球蛋白、总蛋白和尿素，发现至少一种添加的干扰物质的反应存在明显的物种差异。其余分析物受到线性或复杂剂量反应关系的影响，或者仅在干扰物质的最高浓度下受到影响。当血清中存在常见干扰时，这些数据将有助于辅助解释实验室检测结果。
