Sharov Victor S, Schöneich Christian
University of Kansas, Pharmaceutical Chemistry Department, Lawrence, KS 66047, USA.
Expert Rev Proteomics. 2007 Apr;4(2):309-21. doi: 10.1586/14789450.4.2.309.
The scope of the current paper is to review existing and potential applications of proteomic analysis to aging research. The focus will lie on the unique opportunities of high-throughput studies for uncovering specific alterations in protein expression, protein complexes or protein modifications caused by biological aging. The result of such studies will outline aging phenotypes and potentially indicate pathways involved in the pathogenesis of age-associated disfunctions. Specific attention is paid to the illustrations of successful applications of proteomic technologies and potential applications of new proteomic concepts to biogerontological studies.
本文的范围是回顾蛋白质组学分析在衰老研究中的现有及潜在应用。重点将放在高通量研究的独特机遇上，以揭示由生物衰老引起的蛋白质表达、蛋白质复合物或蛋白质修饰的特定变化。此类研究的结果将勾勒出衰老表型，并有可能指出与年龄相关功能障碍发病机制相关的途径。特别关注蛋白质组学技术成功应用的实例以及新蛋白质组学概念在生物老年学研究中的潜在应用。
