Department of Pediatrics, The Johns Hopkins University, Baltimore, MD 21224, USA.
Proteomics Clin Appl. 2013 Aug;7(7-8):477-89. doi: 10.1002/prca.201200138. Epub 2013 Jul 19.
The aging aorta exhibits structural and physiological changes that are reflected in the proteome of its component cells types. The advance in proteomic technologies has made it possible to analyze the quantity of proteins associated with the natural history of aortic aging. These alterations reflect the molecular and cellular mechanisms of aging and could provide an opportunity to predict vascular health. This paper focuses on whether discoveries stemming from the application of proteomic approaches of the intact aging aorta or vascular smooth muscle cells can provide useful insights. Although there have been limited studies to date, a number of interesting proteins have been identified that are closely associated with aging in the rat aorta. Such proteins, including milk fat globule-EGF factor 8, matrix metalloproteinase type-2, and vitronectin, could be used as indicators of vascular health, or even explored as therapeutic targets for aging-related vascular diseases.
衰老的主动脉表现出结构和生理变化，这些变化反映在其组成细胞类型的蛋白质组中。蛋白质组学技术的进步使得分析与主动脉衰老自然史相关的蛋白质的数量成为可能。这些改变反映了衰老的分子和细胞机制，并可能为预测血管健康提供机会。本文重点关注从完整衰老主动脉或血管平滑肌细胞的蛋白质组学方法应用中获得的发现是否可以提供有用的见解。尽管迄今为止的研究有限，但已经鉴定出许多与大鼠主动脉衰老密切相关的有趣蛋白质。这些蛋白质，包括乳脂肪球 EGF 因子 8、基质金属蛋白酶 2 和 vitronectin，可以用作血管健康的指标，甚至可以作为与衰老相关的血管疾病的治疗靶点进行探索。
