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本文引用的文献

1
Low mannose-binding lectin function is associated with sepsis in adult patients.低甘露糖结合凝集素功能与成年患者的败血症相关。
FEMS Immunol Med Microbiol. 2006 Nov;48(2):274-82. doi: 10.1111/j.1574-695X.2006.00144.x.
2
Involvement of complement pathways in patients with bacterial septicemia.补体途径在细菌性败血症患者中的作用。
Mol Immunol. 2007 Mar;44(7):1631-8. doi: 10.1016/j.molimm.2006.08.008. Epub 2006 Oct 17.
3
Mannan-binding lectin pathway deficiencies and invasive fungal infections following allogeneic stem cell transplantation.异基因造血干细胞移植后的甘露糖结合凝集素途径缺陷与侵袭性真菌感染
Exp Hematol. 2006 Oct;34(10):1435-41. doi: 10.1016/j.exphem.2006.06.005.
4
Mannose-binding lectin does not act as an acute-phase reactant in adults with community-acquired pneumococcal pneumonia.甘露糖结合凝集素在社区获得性肺炎成人患者中并非作为一种急性期反应物发挥作用。
Clin Exp Immunol. 2006 Aug;145(2):228-34. doi: 10.1111/j.1365-2249.2006.03140.x.
5
A community outbreak of Legionnaires' disease: evidence of a cooling tower as the source.军团病的社区暴发：冷却塔作为传染源的证据。
Clin Microbiol Infect. 2006 Jul;12(7):642-7. doi: 10.1111/j.1469-0691.2006.01447.x.
6
Mannose binding lectin acute phase activity in patients with severe infection.严重感染患者的甘露糖结合凝集素急性期活性
J Clin Immunol. 2005 Jul;25(4):346-52. doi: 10.1007/s10875-005-4702-1.
7
Heteroligomeric forms of codon 54 mannose binding lectin (MBL) in circulation demonstrate reduced in vitro function.循环中密码子54甘露糖结合凝集素（MBL）的异源寡聚体形式在体外功能降低。
Mol Immunol. 2006 Mar;43(7):950-61. doi: 10.1016/j.molimm.2005.06.023. Epub 2005 Aug 11.
8
Clinical outcomes for hospitalized patients with Legionella pneumonia in the antigenuria era: the influence of levofloxacin therapy.抗原尿时代住院军团菌肺炎患者的临床结局：左氧氟沙星治疗的影响。
Clin Infect Dis. 2005 Mar 15;40(6):794-9. doi: 10.1086/428059. Epub 2005 Feb 17.
9
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease.Toll样受体4基因多态性与军团病抗性相关。
Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2487-9. doi: 10.1073/pnas.0409831102. Epub 2005 Feb 7.
10
An outbreak of Legionnaires' disease at the Melbourne Aquarium, April 2000: investigation and case-control studies.2000年4月墨尔本水族馆军团病暴发：调查与病例对照研究
Med J Aust. 2004 Jun 7;180(11):566-72. doi: 10.5694/j.1326-5377.2004.tb06093.x.

低甘露糖结合凝集素补体激活功能与军团病易感性相关。

Low mannose-binding lectin complement activation function is associated with predisposition to Legionnaires' disease.

作者信息

Eisen D P, Stubbs J, Spilsbury D, Carnie J, Leydon J, Howden B P

机构信息

Clinical Centre for Research Excellence in Infectious Diseases, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia.

出版信息

Clin Exp Immunol. 2007 Jul;149(1):97-102. doi: 10.1111/j.1365-2249.2007.03390.x. Epub 2007 Apr 11.

DOI:10.1111/j.1365-2249.2007.03390.x
PMID:17425652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1942031/
Abstract

Innate immune system deficiency may predispose to severe infections such as Legionnaires' disease. We have investigated the role of mannose-binding lectin (MBL) deficiency in the Melbourne Aquarium Legionnaires' disease outbreak. Serum samples from patients and controls that were exposed but shown to be uninfected from the Melbourne Aquarium Legionnaires' disease outbreak were tested for MBL function (C4 deposition) and level (mannan-binding). MBL function was lower in Legionnaires' disease cases than in age- and sex-matched uninfected, exposed controls. The frequency of MBL deficiency with C4 deposition < 0.2 U/microl was significantly higher in Legionnaires' disease cases than in controls. This also applied to Legionnaires' disease cases requiring hospital care. There was no difference in MBL mannan-binding levels between Legionnaires' disease patients and controls. There was no significant interval change in MBL function or level after a mean of 46 days. MBL complement activation functional deficiency appears to predispose to Legionnaires' disease.

摘要

先天性免疫系统缺陷可能易患严重感染，如军团病。我们研究了甘露糖结合凝集素（MBL）缺陷在墨尔本水族馆军团病暴发中的作用。对墨尔本水族馆军团病暴发中暴露但未感染的患者和对照的血清样本进行了MBL功能（C4沉积）和水平（甘露聚糖结合）检测。军团病病例的MBL功能低于年龄和性别匹配的未感染、暴露对照。C4沉积<0.2 U/微升的MBL缺陷频率在军团病病例中显著高于对照。这也适用于需要住院治疗的军团病病例。军团病患者和对照之间的MBL甘露聚糖结合水平没有差异。平均46天后，MBL功能或水平没有显著的间隔变化。MBL补体激活功能缺陷似乎易患军团病。