一项多方面商业减肥计划的随机试验。

Randomized trial of a multifaceted commercial weight loss program.

作者信息

Rock Cheryl L, Pakiz Bilge, Flatt Shirley W, Quintana Elizabeth L

机构信息

Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, Dept. 0901, La Jolla, CA 92093-0901, USA.

出版信息

Obesity (Silver Spring). 2007 Apr;15(4):939-49. doi: 10.1038/oby.2007.614.

DOI:10.1038/oby.2007.614

PMID:17426329

Abstract

OBJECTIVE

To test whether a commercial weight loss program promotes greater weight loss in overweight or obese women compared with control conditions and to describe the effect on plasma lipids, carotenoids, hormones, and fitness.

RESEARCH METHODS AND PROCEDURES

Overweight or obese women were randomized to commercial weight loss program or control conditions (n=35 each).

RESULTS

At randomization, participants were 41.1 (11.4) (mean [standard deviation]) years, BMI 34.0 (3.5) kg/m2, and weight 92.0 (11.1) kg. At 6 months, change in weight by intent-to-treat (ITT) analysis was -7.2 (6.7) kg and -7.8% (7.2%) in the intervention group vs. -0.3 (3.9) kg and -0.3% (4.5%) in the control group (n=35 for each; p<0.01). One-year ITT analysis revealed significantly greater change in weight, percent weight, BMI, and waist and hip circumferences in the intervention vs. control group. Completers at 1 year exhibited change in weight of -7.3 (10.4) kg for the intervention group (n=32) vs. -0.7 (5.6) kg for controls (n=33) (p<0.01), and -7.8% (11.1%) weight change for the intervention group vs. -0.7% (6.2%) for controls (p<0.01). High-density lipoprotein (HDL) cholesterol concentration increased significantly in the intervention group. Fasting serum insulin decreased in the intervention but increased in the control group at 6 months (p<0.01), remaining different at 1 year (p=0.05).

DISCUSSION

The commercial program successfully facilitated weight loss, which was notably maintained at 1 year, and promoted favorable changes in plasma lipid and hormone concentrations.

摘要

目的

测试与对照条件相比，一项商业减肥计划是否能使超重或肥胖女性实现更大程度的体重减轻，并描述其对血浆脂质、类胡萝卜素、激素和健康状况的影响。

研究方法与步骤

将超重或肥胖女性随机分为商业减肥计划组或对照组（每组n = 35）。

结果

随机分组时，参与者的年龄为41.1（11.4）（均值[标准差]）岁，体重指数（BMI）为34.0（3.5）kg/m²，体重为92.0（11.1）kg。6个月时，干预组意向性分析（ITT）的体重变化为-7.2（6.7）kg，体重下降百分比为-7.8%（7.2%），而对照组的体重变化为-0.3（3.9）kg，体重下降百分比为-0.3%（4.5%）（每组n = 35；p < 0.01）。1年的ITT分析显示，干预组在体重、体重百分比、BMI以及腰围和臀围方面的变化显著大于对照组。1年时的完成者中，干预组（n = 32）的体重变化为-7.3（10.4）kg，而对照组（n = 33）为-0.7（5.6）kg（p < 0.01），干预组的体重变化百分比为-7.8%（11.1%），对照组为-0.7%（6.2%）（p < 0.01）。干预组的高密度脂蛋白（HDL）胆固醇浓度显著升高。干预组空腹血清胰岛素在6个月时下降，而对照组则升高（p < 0.01），1年时仍存在差异（p = 0.05）。