Rock Cheryl L, Pakiz Bilge, Flatt Shirley W, Quintana Elizabeth L
Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, Dept. 0901, La Jolla, CA 92093-0901, USA.
Obesity (Silver Spring). 2007 Apr;15(4):939-49. doi: 10.1038/oby.2007.614.
To test whether a commercial weight loss program promotes greater weight loss in overweight or obese women compared with control conditions and to describe the effect on plasma lipids, carotenoids, hormones, and fitness.
Overweight or obese women were randomized to commercial weight loss program or control conditions (n=35 each).
At randomization, participants were 41.1 (11.4) (mean [standard deviation]) years, BMI 34.0 (3.5) kg/m2, and weight 92.0 (11.1) kg. At 6 months, change in weight by intent-to-treat (ITT) analysis was -7.2 (6.7) kg and -7.8% (7.2%) in the intervention group vs. -0.3 (3.9) kg and -0.3% (4.5%) in the control group (n=35 for each; p<0.01). One-year ITT analysis revealed significantly greater change in weight, percent weight, BMI, and waist and hip circumferences in the intervention vs. control group. Completers at 1 year exhibited change in weight of -7.3 (10.4) kg for the intervention group (n=32) vs. -0.7 (5.6) kg for controls (n=33) (p<0.01), and -7.8% (11.1%) weight change for the intervention group vs. -0.7% (6.2%) for controls (p<0.01). High-density lipoprotein (HDL) cholesterol concentration increased significantly in the intervention group. Fasting serum insulin decreased in the intervention but increased in the control group at 6 months (p<0.01), remaining different at 1 year (p=0.05).
The commercial program successfully facilitated weight loss, which was notably maintained at 1 year, and promoted favorable changes in plasma lipid and hormone concentrations.
测试与对照条件相比，一项商业减肥计划是否能使超重或肥胖女性实现更大程度的体重减轻，并描述其对血浆脂质、类胡萝卜素、激素和健康状况的影响。
将超重或肥胖女性随机分为商业减肥计划组或对照组（每组n = 35）。
随机分组时，参与者的年龄为41.1（11.4）（均值[标准差]）岁，体重指数（BMI）为34.0（3.5）kg/m²，体重为92.0（11.1）kg。6个月时，干预组意向性分析（ITT）的体重变化为-7.2（6.7）kg，体重下降百分比为-7.8%（7.2%），而对照组的体重变化为-0.3（3.9）kg，体重下降百分比为-0.3%（4.5%）（每组n = 35；p < 0.01）。1年的ITT分析显示，干预组在体重、体重百分比、BMI以及腰围和臀围方面的变化显著大于对照组。1年时的完成者中，干预组（n = 32）的体重变化为-7.3（10.4）kg，而对照组（n = 33）为-0.7（5.6）kg（p < 0.01），干预组的体重变化百分比为-7.8%（11.1%），对照组为-0.7%（6.2%）（p < 0.01）。干预组的高密度脂蛋白（HDL）胆固醇浓度显著升高。干预组空腹血清胰岛素在6个月时下降，而对照组则升高（p < 0.01），1年时仍存在差异（p = 0.05）。
该商业计划成功促进了体重减轻，且在1年时显著维持，并促进了血浆脂质和激素浓度的有利变化。
