Kondo Y, Satoh M, Imura N, Akimoto M
Department of Urology, Nippon Medical School, Tokyo, Japan.
Cancer Chemother Pharmacol. 1991;29(1):19-23. doi: 10.1007/BF00686330.
The effects of bismuth nitrate pretreatment on the toxicity and antitumor activity of cis-diamminedichloroplatinum (cisplatin, CDDP) were examined in nude mice that had been inoculated with human bladder-tumor tissue. Pretreatment with bismuth nitrate depressed the renal toxicity of CDDP without compromising its activity against a transplantable human bladder tumor. Renal metallothionein (MT) and bismuth (Bi) levels in nude mice were markedly increased by Bi preadministration, but no significant MT induction was observed in inoculated human bladder-tumor tissue in which only a trace amount of Bi was incorporated. Furthermore, it was confirmed that tumor platinum (Pt) concentrations in CDDP-treated mice were not affected by Bi pretreatment. Thus, the administration of Bi compounds prior to chemotherapy with CDDP may provide an effective mode of treatment for advanced bladder tumors.
在接种了人膀胱肿瘤组织的裸鼠中，研究了硝酸铋预处理对顺二氨二氯铂（顺铂，CDDP）毒性和抗肿瘤活性的影响。硝酸铋预处理降低了CDDP的肾毒性，同时不影响其对可移植人膀胱肿瘤的活性。铋预处理显著提高了裸鼠肾金属硫蛋白（MT）和铋（Bi）水平，但在仅掺入微量铋的接种人膀胱肿瘤组织中未观察到明显的MT诱导。此外，证实了铋预处理不影响CDDP治疗小鼠的肿瘤铂（Pt）浓度。因此，在使用CDDP化疗前给予铋化合物可能为晚期膀胱肿瘤提供一种有效的治疗方式。
