Effect of selenite on renal toxicity and antitumor activity of cis-diamminedichloroplatinum in mice inoculated with Ehrlich ascites tumor cell.

Effect of sodium selenite on renal toxicity and antitumor activity of cis-diamminedichloroplatinum (Cisplatin; CDDP) repeatedly administered to mice inoculated with Ehrlich ascites tumor cells were examined. Simultaneous repeated administration of selenite with CDDP markedly improved the growth depression, the renal toxicity indicated by blood urea nitrogen value and the diarrhea caused by CDDP, and inhibited the growth of Ehrlich ascites tumor cells cooperatively with CDDP. This results suggest that selenium compounds are useful for prevention of the toxic side effects of CDDP.