Crandall Shane R, Adam Murtaza, Kinnischtzke Amanda K, Nick Teresa A
University of Minnesota, Department of Neuroscience and Center for Neurobehavioral Development, 6-145 Jackson Hall, Minneapolis, MN 55455, USA.
J Neurophysiol. 2007 Jul;98(1):232-40. doi: 10.1152/jn.00128.2007. Epub 2007 Apr 11.
Sleep abnormalities are coexpressed with human communication disorders. Recent data from the birdsong system, the best model for human speech, indicate that sleep has a critical role in vocal learning. To understand the neural mechanisms that underlie behavioral changes during sleep, we recorded sleep activity in the song control area HVC longitudinally during song development in zebra finches. We focused on the sensorimotor phase of song learning, when the finch shapes his song behavior toward a learned tutor song model. Direct comparison of sleep activity in adults and juveniles revealed that the juvenile HVC has a lower spike rate and longer silent periods than the adult. Within individual finches, sleep silent periods decreased and spike rate increased with age. We next systematically compared neural sleep activity and song behavior. We now report that spike rate during sleep was significantly correlated with overnight changes in song behavior. Collectively, these data indicate that sleep activity in the vocal control area HVC increases with age and may affect song behavior.
睡眠异常与人类交流障碍同时出现。来自鸟鸣系统（人类言语的最佳模型）的最新数据表明，睡眠在发声学习中起关键作用。为了了解睡眠期间行为变化背后的神经机制，我们在斑胸草雀歌曲发育过程中纵向记录了歌曲控制区域HVC的睡眠活动。我们关注歌曲学习的感觉运动阶段，即雀鸟将其歌曲行为塑造为向学习到的导师歌曲模型靠拢的阶段。对成年和幼年斑胸草雀睡眠活动的直接比较显示，幼年HVC的放电率较低，静息期较长。在个体雀鸟中，睡眠静息期随年龄增长而减少，放电率随年龄增长而增加。接下来，我们系统地比较了神经睡眠活动和歌曲行为。我们现在报告，睡眠期间的放电率与夜间歌曲行为的变化显著相关。总体而言，这些数据表明，发声控制区域HVC的睡眠活动随年龄增长而增加，可能会影响歌曲行为。
