Nielsen Aneta Aleksandra, Nielsen Jens Nederby, Grønbaek Henning, Eivindson Martin, Vind Ida, Munkholm Pia, Brandslund Ivan, Hey Henrik
Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark.
Digestion. 2007;75(1):10-6. doi: 10.1159/000101560. Epub 2007 Apr 10.
Patients with Crohn's disease (CD) often develop malnutrition due to disease activity. We aimed to assess the effect of two different enteral supplements of Impact(R) Powder (IP; Novartis, Switzerland) on leptin levels and nutritional status in active CD patients during prednisolone treatment and tapering.
Thirty-one CD patients were randomized to IP Extra (group 1) or IP Standard (group 2). Leptin levels, nutritional, clinical and biochemical markers were studied at inclusion, after 5 and after 9 weeks of the study.
Leptin levels, body mass index (BMI) and total cholesterol increased significantly within both groups at week 5 compared to inclusion. Leptin levels correlated with BMI in both groups at inclusion and in group 2 at week 9. In group 1, triglyceride levels remained unchanged, while levels in group 2 increased significantly at week 5 compared to inclusion. Clinical and biochemical markers improved during the study compared to inclusion.
Increased leptin levels during the study progress were transient, decreasing due to prednisolone withdrawal at the end of the study. Both formulas used as adjuvant therapy to prednisolone treatment were able to improve nutritional status in CD patients.
克罗恩病（CD）患者常因疾病活动而出现营养不良。我们旨在评估两种不同的安素（Impact(R)）粉（IP；瑞士诺华公司）肠内补充剂对泼尼松龙治疗及减量期间活动性CD患者瘦素水平和营养状况的影响。
31例CD患者被随机分为安素加强组（第1组）或安素标准组（第2组）。在研究纳入时、研究第5周和第9周后，对瘦素水平、营养、临床和生化指标进行研究。
与纳入时相比，两组在第5周时瘦素水平、体重指数（BMI）和总胆固醇均显著升高。在纳入时及第9周时，两组的瘦素水平均与BMI相关，在第2组中二者相关性显著。在第1组中，甘油三酯水平保持不变，而在第2组中，与纳入时相比，第5周时甘油三酯水平显著升高。与纳入时相比，研究期间临床和生化指标有所改善。
研究过程中瘦素水平升高是短暂的，在研究结束时因停用泼尼松龙而下降。两种配方作为泼尼松龙治疗的辅助疗法均能改善CD患者的营养状况。
