Ody C, Jungblut-Ruault S, Cossali D, Barnet M, Aurrand-Lions M, Imhof B A, Matthes T
Department of Pathology and Immunology, University Medical Center, Geneva, Switzerland.
Leukemia. 2007 Jun;21(6):1285-93. doi: 10.1038/sj.leu.2404689. Epub 2007 Apr 12.
Differentiation of naïve B cells into plasma cells or memory cells occurs in the germinal centers (GCs) of lymph follicles or alternatively via a GC- and T-cell-independent pathway. It is currently assumed that B-cell lymphomas correlate to normal B-cell differentiation stages, but the precise correlation of several B-cell lymphomas to these two pathways remains controversial. In the present report, we describe the junctional adhesion molecule C (JAM-C), currently identified at the cell-cell border of endothelial cells, as a new B-cell marker with a tightly regulated expression during B-cell differentiation. Expression of JAM-C in tonsils allows distinction between two CD27+ B-cell subpopulations: JAM-C- GC B cells and JAM-C+ non-germinal B cells. The expression of JAM-C in different B-cell lymphomas reveals a disease-specific pattern and allows a clear distinction between JAM-C- lymphoproliferative syndromes (chronic lymphocytic leukemia, mantle cell lymphoma and follicular lymphoma) and JAM-C+ ones (hairy cell leukemia, marginal zone B-cell lymphoma). Therefore, we propose JAM-C as a new identification tool in B-cell lymphoma diagnosis.
幼稚B细胞分化为浆细胞或记忆细胞发生在淋巴滤泡的生发中心（GCs），或者通过一条不依赖GC和T细胞的途径。目前认为B细胞淋巴瘤与正常B细胞分化阶段相关，但几种B细胞淋巴瘤与这两条途径的确切关联仍存在争议。在本报告中，我们描述了目前在内皮细胞的细胞-细胞边界处发现的连接黏附分子C（JAM-C），它是一种在B细胞分化过程中表达受到严格调控的新型B细胞标志物。JAM-C在扁桃体中的表达使得能够区分两个CD27+B细胞亚群：JAM-C-生发中心B细胞和JAM-C+非生发中心B细胞。JAM-C在不同B细胞淋巴瘤中的表达揭示了一种疾病特异性模式，并且能够明确区分JAM-C-淋巴增殖性综合征（慢性淋巴细胞白血病、套细胞淋巴瘤和滤泡性淋巴瘤）和JAM-C+淋巴增殖性综合征（毛细胞白血病、边缘区B细胞淋巴瘤）。因此，我们提议将JAM-C作为B细胞淋巴瘤诊断中的一种新型鉴定工具。
