Zawodny Piotr, Zawodny Paweł, Kulaszyńska Monika, Stój Elżbieta, Knap-Czechowska Anna, Skonieczna-Żydecka Karolina, Sieńko Jerzy
Medical Center Zawodny Clinic, Ku Słońcu 58, 71-047 Szczecin, Poland.
Department of Plastic, Endocrine and General Surgery, Pomeranian Medical University in Szczecin, Siedlecka 2, 72-010 Police, Poland.
J Clin Med. 2025 Apr 8;14(8):2546. doi: 10.3390/jcm14082546.
: The increasing demand for aesthetic medical treatments has led to advancements in laser therapies, particularly for pigmented and vascular facial lesions. This study compares the efficacy of 532 nm and 755 nm lasers for treating facial pigmented and vascular lesions. : Data extraction was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Primary outcomes included the (i) improvement and (ii) pain sensation. Secondary outcomes included the occurrence of adverse events. A random-effects meta-analysis was conducted for outcomes where two or more studies provided data. Continuous outcomes were analyzed using pooled standardized mean differences, while nominal outcomes were assessed using pooled risk ratios in endpoints, using observed cases only. : A total of 16 studies involving 509 participants were included. No significant difference in overall improvement between the 532 nm and 755 nm lasers was found. Subgroup analysis showed a slight advantage in the 755 nm group for lesion improvement (RR = 1.512, 95% CI [1.070, 2.136], = 0.019). Adverse event occurrence was minimal, with no significant differences between the laser types, however the pain score was higher for the 532 nm laser (SMD = -1.336, SE = 0.636, 95% CI [-2.582, -0.09], = 0.036). No publication bias with respect to any evaluated intervention was detected. : This meta-analysis concludes that both 532 nm and 755 nm lasers are effective in treating facial pigmented and vascular lesions, with the 755 nm laser showing a slight advantage and the 532 nm one producing more painful experiences but fewer adverse events in the case of vascular lesions.
对美容医疗治疗的需求不断增加，推动了激光疗法的发展，尤其是在治疗面部色素沉着和血管性病变方面。本研究比较了532纳米和755纳米激光治疗面部色素沉着和血管性病变的疗效。：数据提取按照系统评价和Meta分析的首选报告项目（PRISMA）进行。主要结局包括：（i）改善情况和（ii）疼痛感觉。次要结局包括不良事件的发生。对于两项或更多研究提供数据的结局进行随机效应Meta分析。连续结局使用合并标准化均数差值进行分析，而名义结局仅使用观察病例，在终点使用合并风险比进行评估。：共纳入16项研究，涉及509名参与者。532纳米和755纳米激光在总体改善方面未发现显著差异。亚组分析显示，755纳米组在病变改善方面略有优势（RR = 1.512，95%CI [1.070, 2.136]， = 0.019）。不良事件发生率极低，激光类型之间无显著差异，然而532纳米激光的疼痛评分更高（SMD = -1.336，SE = 0.636，95%CI [-2.582, -0.09]， = 0.036）。未检测到任何评估干预措施存在发表偏倚。：这项Meta分析得出结论，532纳米和755纳米激光在治疗面部色素沉着和血管性病变方面均有效，755纳米激光显示出轻微优势，532纳米激光在治疗血管性病变时产生的疼痛更强烈，但不良事件较少。
