β-肾上腺素能受体阻断药：泪液溶菌酶及不良反应的免疫学筛查
Beta-adrenergic receptor blocking drugs: tear lysozyme and immunological screening for adverse reaction.
作者信息
Mackie I A, Seal D V, Pescod J M
出版信息
Br J Ophthalmol. 1977 May;61(5):354-9. doi: 10.1136/bjo.61.5.354.
Abstract
Patients who had received long-term therapy with practolol and other beta-adrenergic receptor blocking drugs were examined ophthalmologically. Tear lysozyme concentration and serum autoantibodies (antinuclear antibodies, DNA-binding antibodies and intercellular cement substance antibodies) were measured. It was found that beta-adrenergic receptor blocking drugs may have a pharmacological effect on the lachrymal glands, but this was not associated with dry eyes or adverse reaction. Practolol was found to be capable of reducing tear lysozyme concentrations to very low levels, and this was initially associated with high titres of ICC antibody. No other drug tested produced these effects.
摘要
对接受过心得宁及其他β-肾上腺素能受体阻断药长期治疗的患者进行了眼科检查。检测了泪液溶菌酶浓度和血清自身抗体（抗核抗体、DNA结合抗体和细胞间黏合物质抗体）。结果发现，β-肾上腺素能受体阻断药可能对泪腺有药理作用，但这与干眼或不良反应无关。发现心得宁能够将泪液溶菌酶浓度降低到非常低的水平，并且这最初与高滴度的细胞间黏合物质抗体相关。所测试的其他药物均未产生这些效应。
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