β-肾上腺素能受体阻断药：泪液溶菌酶及不良反应的免疫学筛查
Beta-adrenergic receptor blocking drugs: tear lysozyme and immunological screening for adverse reaction.
作者信息
Mackie I A, Seal D V, Pescod J M
出版信息
Br J Ophthalmol. 1977 May;61(5):354-9. doi: 10.1136/bjo.61.5.354.
Abstract
Patients who had received long-term therapy with practolol and other beta-adrenergic receptor blocking drugs were examined ophthalmologically. Tear lysozyme concentration and serum autoantibodies (antinuclear antibodies, DNA-binding antibodies and intercellular cement substance antibodies) were measured. It was found that beta-adrenergic receptor blocking drugs may have a pharmacological effect on the lachrymal glands, but this was not associated with dry eyes or adverse reaction. Practolol was found to be capable of reducing tear lysozyme concentrations to very low levels, and this was initially associated with high titres of ICC antibody. No other drug tested produced these effects.
摘要
对接受过心得宁及其他β-肾上腺素能受体阻断药长期治疗的患者进行了眼科检查。检测了泪液溶菌酶浓度和血清自身抗体（抗核抗体、DNA结合抗体和细胞间黏合物质抗体）。结果发现，β-肾上腺素能受体阻断药可能对泪腺有药理作用，但这与干眼或不良反应无关。发现心得宁能够将泪液溶菌酶浓度降低到非常低的水平，并且这最初与高滴度的细胞间黏合物质抗体相关。所测试的其他药物均未产生这些效应。
相似文献
1
Beta-adrenergic receptor blocking drugs: tear lysozyme and immunological screening for adverse reaction.β-肾上腺素能受体阻断药：泪液溶菌酶及不良反应的免疫学筛查
Br J Ophthalmol. 1977 May;61(5):354-9. doi: 10.1136/bjo.61.5.354.
2
Effects of long-term treatment with timolol on lacrimal gland function.噻吗洛尔长期治疗对泪腺功能的影响。
Br J Ophthalmol. 1981 Sep;65(9):603-5. doi: 10.1136/bjo.65.9.603.
3
Beta-blockers, eye complaints, and tear secretion.β受体阻滞剂、眼部不适与泪液分泌
Lancet. 1977 Nov 12;2(8046):1027. doi: 10.1016/s0140-6736(77)92920-8.
4
The influence of long-term treatment with timolol on human tear lysozyme albumin content.噻吗洛尔长期治疗对人泪液溶菌酶白蛋白含量的影响。
Graefes Arch Clin Exp Ophthalmol. 1982;218(2):93-5. doi: 10.1007/BF02153718.
5
Quantitative tear lysozyme assay in units of activity per microlitre.以每微升活性单位进行的定量泪液溶菌酶测定。
Br J Ophthalmol. 1976 Jan;60(1):70-4. doi: 10.1136/bjo.60.1.70.
6
Ocular effects of beta-blocking therapy.
Trans Ophthalmol Soc U K (1962). 1977 Sep;97(4):510-3.
7
[Iatrogenic dermatoses caused by beta-blocking drugs].[β受体阻滞剂所致医源性皮肤病]
G Ital Dermatol Venereol. 1983 Nov-Dec;118(6):341-8.
8
Tear fluid lysozyme concentration: guide to practolol toxicity.泪液溶菌酶浓度：心得宁中毒的指标
Br Med J. 1975 Dec 27;4(5999):732. doi: 10.1136/bmj.4.5999.732.
9
Lysozyme, alfa-1-antitrypsin and serum albumin in tear fluid of timolol treated glaucoma patients with and without symptoms of dry eyes.噻吗洛尔治疗的青光眼患者泪液中的溶菌酶、α-1抗胰蛋白酶和血清白蛋白，伴有或不伴有干眼症状
Acta Ophthalmol (Copenh). 1981 Aug;59(4):503-9. doi: 10.1111/j.1755-3768.1981.tb08335.x.
10
Immunohistochemical localization of human tear lysozyme.
Arch Ophthalmol. 1981 Feb;99(2):298-300. doi: 10.1001/archopht.1981.03930010300016.
引用本文的文献
1
An Evidence-Based Strategic Approach to Prevention and Treatment of Dry Eye Disease, a Modern Global Epidemic.一种基于证据的预防和治疗干眼病的战略方法，干眼病是一种现代全球性流行病。
Healthcare (Basel). 2021 Jan 17;9(1):89. doi: 10.3390/healthcare9010089.
2
Preservative-Free Prostaglandin Analogs and Prostaglandin/Timolol Fixed Combinations in the Treatment of Glaucoma: Efficacy, Safety and Potential Advantages.无防腐剂前列腺素类似物和前列腺素/噻吗洛尔固定组合治疗青光眼：疗效、安全性和潜在优势。
Drugs. 2018 Jan;78(1):39-64. doi: 10.1007/s40265-017-0843-9.
3
Practical issues concerning tear protein assays in dry eye.干眼患者泪液蛋白质检测的实际问题
Eye Vis (Lond). 2014 Nov 13;1:6. doi: 10.1186/s40662-014-0006-y. eCollection 2014.
4
The questionably dry eye.可疑的干眼症
Br J Ophthalmol. 1981 Jan;65(1):2-9. doi: 10.1136/bjo.65.1.2.
5
Quantitative tear lysozyme assay: a new technique for transporting specimens.定量泪液溶菌酶检测：一种运送标本的新技术。
Br J Ophthalmol. 1980 Sep;64(9):700-4. doi: 10.1136/bjo.64.9.700.
6
Effects of long-term treatment with timolol on lacrimal gland function.噻吗洛尔长期治疗对泪腺功能的影响。
Br J Ophthalmol. 1981 Sep;65(9):603-5. doi: 10.1136/bjo.65.9.603.
7
Effects of timolol on corneal sensitivity and tear production.
Int Ophthalmol. 1980 Dec;3(1):25-9. doi: 10.1007/BF00136210.
8
Effects of timolol maleate on tear flow in human eyes.马来酸噻吗洛尔对人眼泪液分泌的影响。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;213(1):19-22. doi: 10.1007/BF02391207.
9
Human tear lysozyme. A comparison of electro-immunodiffusion, radial immunodiffusion and a spectrophotometric assay.
Graefes Arch Clin Exp Ophthalmol. 1982;218(5):265-70. doi: 10.1007/BF02175895.
10
Diagnostic implications of tear protein profiles.泪液蛋白质谱的诊断意义。
Br J Ophthalmol. 1984 May;68(5):321-4. doi: 10.1136/bjo.68.5.321.
本文引用的文献
1
Filter-paper electrophoresis of tears. I. Lysozyme and its correlation with keratoconjunctivitis sicca.泪液的滤纸电泳。I. 溶菌酶及其与干燥性角结膜炎的相关性。
Am J Ophthalmol. 1955 Feb;39(2 Pt 2):200-2.
2
Evaluation of the Schirmer Tear Test.泪液分泌试验评估
South Med J. 1970 Nov;63(11):1256 passim. doi: 10.1097/00007611-197011000-00013.
3
[Pemphigus-like and pemphigoid-like antibodies].[类天疱疮样和类天疱疮抗体]
Dermatologica. 1970;140(5):310-7.
4
Pemphigus and other diseases. Results of indirect intercellular immunofluorescence.天疱疮及其他疾病。间接细胞间免疫荧光检测结果
Arch Dermatol. 1970 May;101(5):538-46.
5
Proceedings: The lysozyme agar diffusion test in the sicca syndrome.论文集：干燥综合征中的溶菌酶琼脂扩散试验
Ophthalmologica. 1973;167(5):429-32. doi: 10.1159/000306987.
6
Letter: cutaneous and ocular reactions to practolol.信函：心得宁的皮肤及眼部反应。
Br Med J. 1974 Dec 14;4(5945):653. doi: 10.1136/bmj.4.5945.653.
7
Letter: Skin reactions to beta-blockers.信件：β受体阻滞剂引起的皮肤反应。
Br Med J. 1974 Nov 30;4(5943):528. doi: 10.1136/bmj.4.5943.528-a.
8
Cutaneous and ocular reactions to practolol.心得宁的皮肤及眼部反应。
Br Med J. 1974 Nov 9;4(5940):321-4. doi: 10.1136/bmj.4.5940.321.
9
Lupus-like syndrome induced by procainamide.普鲁卡因胺诱发的狼疮样综合征。
Am J Cardiol. 1967 Sep;20(3):367-73. doi: 10.1016/0002-9149(67)90060-4.
10
Systemic lupus erythematosus syndrome induced by practolol.心得宁诱发的系统性红斑狼疮综合征
Br Med J. 1973 May 26;2(5864):452-5. doi: 10.1136/bmj.2.5864.452.
Zotero 插件