心得宁诱发的系统性红斑狼疮综合征
Systemic lupus erythematosus syndrome induced by practolol.
作者信息
Raftery E B, Denman A M
出版信息
Br Med J. 1973 May 26;2(5864):452-5. doi: 10.1136/bmj.2.5864.452.
Abstract
Three patients with angina pectoris treated with practolol in varying doses developed a syndrome of arthralgia, particularly of the small joints of the hands, rash, fever, a raised E.S.R., and positive tests for lupus erythematosus (L.E.) cells and antinuclear antibody. The syndrome responded partly to withdrawal of the drug, but steroids were required to produce adequate symptomatic improvement. These disease features suggest that this is an example of drug-induced systemic lupus erythematosus (S.L.E.). The impaired ability of lymphocytes from these patients to transform in vitro indicates a testable hypothesis for the pathogenesis of the syndrome.
摘要
三名接受不同剂量心得宁治疗的心绞痛患者出现了关节痛综合征，尤其是手部小关节疼痛、皮疹、发热、血沉升高，以及红斑狼疮（L.E.）细胞和抗核抗体检测呈阳性。该综合征在部分程度上对停药有反应，但需要使用类固醇来实现充分的症状改善。这些疾病特征表明这是药物诱发的系统性红斑狼疮（S.L.E.）的一个实例。这些患者的淋巴细胞在体外转化能力受损，这为该综合征的发病机制提出了一个可检验的假设。
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