van der Grond J, Laven J S, Lock M T, te Velde E R, Mali W P
Department of Radiodiagnosis, University Hospital Utrecht, The Netherlands.
Fertil Steril. 1991 Dec;56(6):1136-42. doi: 10.1016/s0015-0282(16)54729-3.
To determine if testicular 31P magnetic resonance (MR) spectroscopy can be of additional clinical value.
A controlled study in three selected subjects groups.
All participants were referred to the outpatient clinic of our Department of Obstetrics and Gynecology.
Normal healthy volunteers (n = 13), oligozoospermic (n = 14), and azoospermic patients (n = 17; 6 with epididymal obstruction and 11 with severe germ cell depletion) were selected on the basis of semen analysis, hormone determinations, and, if necessary, on operative exploration.
Magnetic resonance spectroscopy was performed on a Philips Gyroscan S15 (Philips Medical Systems, Best, the Netherlands).
MAIN OUTCOME MEASURE(S): The routine clinical analyses were compared with the outcome of testicular MR spectroscopy to test the hypothesis that MR spectroscopy can be of additional value in the diagnosis of idiopathic oligozoospermic or azoospermic patients.
The MR spectra of normal volunteers were significantly different from oligozoospermic patients (P less than 0.001), from azoospermic patients with germ cell depletion (P less than 0.001), and from azoospermic patients with an obstruction (P less than 0.05). Between the two azoospermic groups also a significant difference was found (P less than 0.001).
These results show that MR spectroscopy is a reliable technique to monitor the testicular function.
确定睾丸31P磁共振（MR）波谱是否具有额外的临床价值。
在三个选定的受试者组中进行的对照研究。
所有参与者均被转诊至我们妇产科门诊。
根据精液分析、激素测定，并在必要时通过手术探查，选取正常健康志愿者（n = 13）、少精子症患者（n = 14）和无精子症患者（n = 17；6例附睾梗阻，11例严重生殖细胞耗竭）。
使用飞利浦Gyroscan S15（飞利浦医疗系统公司，荷兰贝斯特）进行磁共振波谱分析。
将常规临床分析结果与睾丸MR波谱分析结果进行比较，以检验MR波谱在特发性少精子症或无精子症患者诊断中是否具有额外价值这一假设。
正常志愿者的MR波谱与少精子症患者（P < 0.001）、生殖细胞耗竭的无精子症患者（P < 0.001）以及附睾梗阻的无精子症患者（P < 0.05）有显著差异。在两组无精子症患者之间也发现了显著差异（P < 0.001）。
这些结果表明MR波谱是监测睾丸功能的可靠技术。
