van der Grond J, Laven J S, te Velde E R, Mali W P
Department of Radiodiagnosis, University Hospital Utrecht, The Netherlands.
Radiology. 1991 May;179(2):433-6. doi: 10.1148/radiology.179.2.2014287.
Phosphorus-31 MR spectroscopy of the human testis was performed on healthy volunteers (n = 17) and oligospermic (n = 7) and azoospermic patients (n = 4). All patients in the latter group had the Sertoli-cell-only syndrome. Determination of the ratios of phosphomonoesters (PMs) to adenosine triphosphate (ATP), phosphodiesters (PDs) to ATP, and inorganic phosphate (Pi) to ATP made it possible to discriminate among these three groups. The testicular PM/ATP ratio was 1.71 +/- 0.03 (mean +/- standard deviation) in the healthy volunteers and dropped to 1.41 +/- 0.06 (P less than .001 in comparison with healthy volunteers) in the oligospermic patients and to 1.22 +/- 0.07 (P less than .001) in the azoospermic patients. The testicular PD/ATP ratio did show a slight increase from 0.52 +/- 0.10 in healthy volunteers to 0.68 +/- 0.09 (not significant) for oligospermic patients and to 0.83 +/- 0.10 (P less than .01) for azoospermic patients. The Pi/ATP ratio did not show significant differences between healthy volunteers (0.12 +/- 0.07) and oligospermic patients (0.23 +/- 0.08) but was elevated in the azoospermic patients (0.79 +/- 0.12) (P less than .001).
对健康志愿者（n = 17）、少精子症患者（n = 7）和无精子症患者（n = 4）进行了人体睾丸的磷 - 31磁共振波谱分析。后一组的所有患者均患有唯支持细胞综合征。通过测定磷酸单酯（PMs）与三磷酸腺苷（ATP）的比值、磷酸二酯（PDs）与ATP的比值以及无机磷酸盐（Pi）与ATP的比值，能够区分这三组。健康志愿者的睾丸PM/ATP比值为1.71±0.03（平均值±标准差），少精子症患者降至1.41±0.06（与健康志愿者相比，P<0.001），无精子症患者降至1.22±0.07（P<0.001）。睾丸PD/ATP比值确实略有升高，从健康志愿者的0.52±0.10升至少精子症患者的0.68±0.09（无显著性差异），无精子症患者升至0.83±0.10（P<0.01）。Pi/ATP比值在健康志愿者（0.12±0.07）和少精子症患者（0.23±0.08）之间无显著差异，但在无精子症患者中升高（0.79±0.12）（P<0.001）。
