Kaiser W A, Pauleit D, Träber F, Köhler U, Reiser M
Radiologische Universitätsklinik, Bonn.
Rofo. 1992 Nov;157(5):458-65. doi: 10.1055/s-2008-1033042.
In vivo 31P-NMR spectra of heart muscle were obtained in 7 patients with dilating cardiomyopathies and in 10 normal subjects, using an ISIS technique with a 1.5 Tesla body scanner (Philips Gyroscan S15) and the results of the two groups were compared. These results were easily reproduced. In patients with cardiomyopathy there was a significant (p < 0.05) reduction of the PCr/ATP ratio as an expression of abnormal energy metabolism. Two patients with mild clinical symptoms and only slightly reduced functional measurements showed no significant changes in the 31P-NMR spectrum. The patients with the largest reduction of the PCr/ATP index also showed the most marked changes in functional measurements. The PCr/ATP ratio (as also suggested by animal experiments) appears to be a suitable non-invasive indicator for the diagnosis and staging of myocardial changes in dilating cardiomyopathies.
使用1.5特斯拉全身扫描仪（飞利浦Gyroscan S15）的ISIS技术，获取了7例扩张型心肌病患者和10名正常受试者的心肌活体31P-NMR光谱，并对两组结果进行了比较。这些结果很容易重现。在心肌病患者中，作为异常能量代谢的一种表现，磷酸肌酸/三磷酸腺苷（PCr/ATP）比值显著降低（p < 0.05）。两名临床症状较轻且功能测量仅略有降低的患者，其31P-NMR光谱无显著变化。PCr/ATP指数降低幅度最大的患者，其功能测量变化也最为明显。PCr/ATP比值（动物实验也表明）似乎是诊断和分期扩张型心肌病心肌变化的合适非侵入性指标。
