Burke J M, Morrical D, Miller J E
Dale Bumpers Small Farms Research Center, USDA, ARS, Booneville, AR 72927, USA.
Vet Parasitol. 2007 May 31;146(3-4):372-5. doi: 10.1016/j.vetpar.2007.03.013. Epub 2007 Apr 11.
Copper oxide wire particles (COWP) have been used to reduce infection of Haemonchus contortus in hair breed lambs in southeastern USA without signs of copper toxicity. However, copper sensitivity among breeds and regions varies. The objective was to determine the effectiveness and safety of COWP in lactating Polypay ewes and their offspring grazing alfalfa/bluegrass pasture in a rotational grazing system. Mature Polypay ewes were administered 0, 0.5, 1, or 2 g (n=8 or 9/dose) COWP approximately 60 days after lambing in mid-July 2005. Their offspring were administered 0 (n=6), 0.5 or 0.75 g (n=9), 1 or 2 g (n=6) COWP 2 weeks later in late July. The primary gastrointestinal nematode was H. contortus (70%). Between Days 7 and 35, FEC were greater in 0 and 0.5 g COWP groups compared with ewes administered 2 g COWP (COWP x day, P<0.004). PCV decreased in all groups of ewes between Days 0 and 21 (day, P<0.001). Aspartate aminotransferase (AST) activity, a measure of liver copper levels, and body weight was similar among groups of ewes. FEC decreased within 7 days in COWP-treated compared with untreated lambs and remained low throughout experiment (COWP x day, P<0.05). PCV increased in COWP-treated lambs between Days 7 and 35 and decreased in untreated lambs between Days 0 and 21 (COWP x day, P<0.009). AST activity was similar among groups of lambs. Administration of 2 g COWP to ewes prevented a rise in FEC, but a dose of 0.5 g was ineffective as an anthelmintic. Administration of all doses of COWP to lambs decreased FEC and increased PCV compared to untreated lambs. There were no signs of copper toxicity in ewes or lambs. Alternative suppression of H. contortus infections may be necessary in ewes, but COWP was effective in H. contortus management for lambs.
在美国东南部，氧化铜丝颗粒（COWP）已被用于减少毛用品种羔羊的捻转血矛线虫感染，且未出现铜中毒迹象。然而，不同品种和地区对铜的敏感性存在差异。本研究的目的是确定在轮牧系统中，COWP对哺乳的波利佩母羊及其在苜蓿/早熟禾牧场放牧的后代的有效性和安全性。2005年7月中旬产羔后约60天，对成年波利佩母羊分别给予0、0.5、1或2克（每组8或9只）COWP。两周后的7月下旬，给它们的后代分别给予0（每组6只）、0.5或0.75克（每组9只）、1或2克（每组6只）COWP。主要的胃肠道线虫为捻转血矛线虫（占70%）。在第7天至第35天期间，与给予2克COWP的母羊相比，给予0和0.5克COWP组的粪便虫卵计数（FEC）更高（COWP×天数，P<0.004）。在第0天至第21天期间，所有母羊组的红细胞压积（PCV）均下降（天数，P<0.001）。作为肝脏铜水平指标的天冬氨酸转氨酶（AST）活性以及母羊体重在各母羊组之间相似。与未处理的羔羊相比，COWP处理的羔羊在7天内FEC下降，且在整个试验过程中保持较低水平（COWP×天数，P<0.05）。在第7天至第35天期间，COWP处理的羔羊PCV升高，而在第0天至第21天期间，未处理的羔羊PCV下降（COWP×天数，P<0.009）。各羔羊组的AST活性相似。给母羊给予2克COWP可防止FEC升高，但0.5克剂量作为驱虫剂无效。与未处理的羔羊相比，给羔羊给予所有剂量的COWP均降低了FEC并提高了PCV。母羊和羔羊均未出现铜中毒迹象。对于母羊，可能需要采取其他方法来抑制捻转血矛线虫感染，但COWP对羔羊的捻转血矛线虫防治有效。
