Lam Kin S
Nereus Pharmaceuticals Inc., 10480 Wateridge Circle, San Diego, CA 92121, USA.
Trends Microbiol. 2007 Jun;15(6):279-89. doi: 10.1016/j.tim.2007.04.001. Epub 2007 Apr 11.
During the past 15 years, most large pharmaceutical companies have decreased the screening of natural products for drug discovery in favor of synthetic compound libraries. Main reasons for this include the incompatibility of natural product libraries with high-throughput screening and the marginal improvement in core technologies for natural product screening in the late 1980s and early 1990 s. Recently, the development of new technologies has revolutionized the screening of natural products. Applying these technologies compensates for the inherent limitations of natural products and offers a unique opportunity to re-establish natural products as a major source for drug discovery. Examples of these new advances and technologies are described in this review.
在过去的15年里，大多数大型制药公司都减少了对用于药物发现的天然产物的筛选，转而青睐合成化合物库。这样做的主要原因包括天然产物库与高通量筛选不兼容，以及20世纪80年代末和90年代初天然产物筛选核心技术的改进有限。最近，新技术的发展彻底改变了天然产物的筛选。应用这些技术弥补了天然产物的固有局限性，并提供了一个将天然产物重新确立为药物发现主要来源的独特机会。本综述将介绍这些新进展和新技术的实例。
