Veniaminova Natalia A, Vassetzky Nikita S, Kramerov Dmitri A
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, Moscow 119991, Russia.
Genomics. 2007 Jun;89(6):678-86. doi: 10.1016/j.ygeno.2007.02.007. Epub 2007 Apr 12.
B1 SINEs were studied in 22 families covering all major rodent lineages. The number of B1 copies considerably varies, from 1 x 10(4) in Geomyidae to 1 x 10(6) in Myodonta. B1 sequences can be divided into three main structural variants: B1 with a 20-bp tandem duplication (found in Gliridae, Sciuridae, and Aplodontidae), B1 with a 29-bp duplication (found in other families), and proto-B1 without duplication (pB1). These variants can be further subdivided according to their characters, including specific 7-, 9-, or 10-bp deletions. Different B1 subfamilies predominate in different rodent families. The analysis of B1 variants allowed us to propose possible pathways for the evolution of this SINE in the context of rodent evolution.
在涵盖所有主要啮齿动物谱系的22个家族中研究了B1短散在重复元件（SINEs）。B1拷贝数差异很大，从囊鼠科的1×10⁴个到鼠形亚目的1×10⁶个不等。B1序列可分为三种主要结构变体：具有20个碱基对串联重复的B1（见于睡鼠科、松鼠科和河狸鼠科）、具有29个碱基对重复的B1（见于其他家族）以及无重复的原始B1（pB1）。这些变体可根据其特征进一步细分，包括特定的7个、9个或10个碱基对的缺失。不同的B1亚家族在不同的啮齿动物家族中占主导地位。对B1变体的分析使我们能够在啮齿动物进化的背景下提出该SINE进化的可能途径。
