Davenport Miles P, Price David A, McMichael Andrew J
Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington NSW, Australia.
Curr Opin Immunol. 2007 Jun;19(3):294-300. doi: 10.1016/j.coi.2007.04.001. Epub 2007 Apr 12.
Most currently available vaccines target acute infectious agents such as polio, smallpox and influenza virus. The development of vaccines to persistent infectious agents has proven much more difficult. Although it is possible to generate T cell responses to such viruses, these responses are currently unable to prevent the establishment of infection, and immune control may be lost during the chronic phase. Recent advances have increased our understanding of the interactions between persistent viruses and the available T cell repertoire, and will guide approaches to the generation and maintenance of an 'ideal' T cell response.
目前大多数可用疫苗针对的是急性感染病原体，如脊髓灰质炎病毒、天花病毒和流感病毒。事实证明，开发针对持续性感染病原体的疫苗要困难得多。尽管有可能产生针对此类病毒的T细胞反应，但目前这些反应无法预防感染的发生，而且在慢性期可能会失去免疫控制。最近的进展增进了我们对持续性病毒与现有T细胞库之间相互作用的理解，并将指导产生和维持“理想”T细胞反应的方法。
