Black Peter N
Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.
Curr Opin Pharmacol. 2007 Jun;7(3):266-71. doi: 10.1016/j.coph.2006.11.013. Epub 2007 Apr 12.
Infection with Chlamydophila pneumoniae or Mycoplasma pneumoniae has been linked to asthma. There is evidence to suggest that persistent infection with these organisms might lead to an increase in the severity of asthma. beta-Lactam antibiotics have not been shown to be beneficial in the treatment of asthma but several studies have indicated that macrolides and related antibiotics might be useful both for the treatment of chronic asthma and for acute exacerbations. However, these observations need to be confirmed in further studies. It is not clear whether any effect that these antibiotics has is a result of antimicrobial actions against organisms such as C. pneumoniae or whether it is due to their anti-inflammatory action.
肺炎衣原体或肺炎支原体感染与哮喘有关。有证据表明，这些病原体的持续感染可能导致哮喘病情加重。β-内酰胺类抗生素尚未显示对哮喘治疗有益，但多项研究表明，大环内酯类及相关抗生素可能对慢性哮喘治疗和急性加重期治疗均有用。然而，这些观察结果需要在进一步研究中得到证实。目前尚不清楚这些抗生素的任何作用是由于对肺炎衣原体等病原体的抗菌作用，还是由于其抗炎作用。
