David C N, Fujisawa T, Bosch T C
Zoological Institute, University of Munich, Federal Republic of Germany.
Dev Biol. 1991 Dec;148(2):501-7. doi: 10.1016/0012-1606(91)90268-8.
We have examined the growth behavior of small numbers of interstitial stem cells transplanted into tissue of genetically unrelated strains of Hydra magnipapillata. We show that such stem cells, which are at low density following transplantation, proliferate more rapidly than the stem cells of the host, which are at normal density. The rapid proliferation is similar to the proliferation rate of stem cells transplanted into interstitial cell free tissue. The results suggest that stem cells transplanted into heterotypic tissue are unable to "sense" the presence of host stem cells and to adopt their growth rate to that of the surrounding cells. Thus, the feedback signal which negatively regulates stem cell growth as a function of stem cell density must be strain specific.
我们已经研究了少量间充质干细胞移植到与基因无关的巨型乳头水螅品系组织中的生长行为。我们发现，移植后处于低密度状态的此类干细胞比处于正常密度的宿主干细胞增殖更快。这种快速增殖类似于移植到无间充质细胞组织中的干细胞的增殖速率。结果表明，移植到异型组织中的干细胞无法“感知”宿主干细胞的存在，也无法使其生长速率与周围细胞的生长速率相匹配。因此，作为干细胞密度的函数对干细胞生长进行负调控的反馈信号必定具有品系特异性。
