FTO基因中的一种常见变异与体重指数相关，并易导致儿童期和成年期肥胖。
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
作者信息
Frayling Timothy M, Timpson Nicholas J, Weedon Michael N, Zeggini Eleftheria, Freathy Rachel M, Lindgren Cecilia M, Perry John R B, Elliott Katherine S, Lango Hana, Rayner Nigel W, Shields Beverley, Harries Lorna W, Barrett Jeffrey C, Ellard Sian, Groves Christopher J, Knight Bridget, Patch Ann-Marie, Ness Andrew R, Ebrahim Shah, Lawlor Debbie A, Ring Susan M, Ben-Shlomo Yoav, Jarvelin Marjo-Riitta, Sovio Ulla, Bennett Amanda J, Melzer David, Ferrucci Luigi, Loos Ruth J F, Barroso Inês, Wareham Nicholas J, Karpe Fredrik, Owen Katharine R, Cardon Lon R, Walker Mark, Hitman Graham A, Palmer Colin N A, Doney Alex S F, Morris Andrew D, Smith George Davey, Hattersley Andrew T, McCarthy Mark I
机构信息
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK.
出版信息
Science. 2007 May 11;316(5826):889-94. doi: 10.1126/science.1141634. Epub 2007 Apr 12.
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.
肥胖是一个严重的国际健康问题，它会增加多种常见疾病的风险。人们对导致肥胖的遗传因素了解甚少。一项全基因组搜索2型糖尿病易感基因的研究发现，FTO（脂肪量和肥胖相关）基因中的一个常见变异通过对体重指数（BMI）的影响而使人易患糖尿病。该变异与BMI的加性关联在13个队列、38759名参与者中得到了重复验证。与未继承风险等位基因的成年人相比，16%的该风险等位基因纯合子成年人体重约重3千克，肥胖几率增加了1.67倍。这种关联在7岁及以上人群中都有观察到，反映出脂肪量的特定增加。
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