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Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin.JIL-1组蛋白H3S10激酶的功能缺失等位基因增强了果蝇异染色质中着丝粒周围位点的位置效应斑驳。
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2
Reduced levels of Su(var)3-9 but not Su(var)2-5 (HP1) counteract the effects on chromatin structure and viability in loss-of-function mutants of the JIL-1 histone H3S10 kinase.Su(var)3-9水平降低而非Su(var)2-5（HP1）水平降低，可抵消JIL-1组蛋白H3S10激酶功能丧失突变体对染色质结构和生存力的影响。
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3
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The effect of JIL-1 on position-effect variegation is proportional to the total amount of heterochromatin in the genome.JIL-1对位置效应斑驳的影响与基因组中异染色质的总量成正比。
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本文引用的文献

1
Chromatin structure and the regulation of gene expression: the lessons of PEV in Drosophila.染色质结构与基因表达调控：果蝇中位置效应斑驳的启示
Adv Genet. 2008;61:1-43. doi: 10.1016/S0065-2660(07)00001-6.
2
Regulation of chromatin structure by histone H3S10 phosphorylation.组蛋白H3S10磷酸化对染色质结构的调控。
Chromosome Res. 2006;14(4):393-404. doi: 10.1007/s10577-006-1063-4.
3
Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila.JIL-1激酶的功能丧失等位基因是果蝇中wm4等位基因位置效应斑驳的强抑制因子。
Genetics. 2006 Aug;173(4):2403-6. doi: 10.1534/genetics.106.059253. Epub 2006 May 15.
4
Variegation in Drosophila and the Inert Chromosome Regions.果蝇中的斑纹现象与惰性染色体区域
Proc Natl Acad Sci U S A. 1936 Jan;22(1):27-33. doi: 10.1073/pnas.22.1.27.
5
The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila.JIL-1组蛋白H3S10激酶调控果蝇中H3K9二甲基化修饰和异染色质扩展。
Development. 2006 Jan;133(2):229-35. doi: 10.1242/dev.02199. Epub 2005 Dec 8.
6
JIL-1 kinase, a member of the male-specific lethal (MSL) complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila.JIL-1激酶是雄性特异性致死（MSL）复合物的成员之一，对于果蝇眼睛色素沉着的适当剂量补偿是必需的。
Genesis. 2005 Dec;43(4):213-5. doi: 10.1002/gene.20172.
7
The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes.JIL-1激酶调控果蝇多线染色体的结构。
Chromosoma. 2005 Aug;114(3):173-82. doi: 10.1007/s00412-005-0006-8. Epub 2005 Jun 29.
8
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila.Su(var)基因调控果蝇常染色质和异染色质之间的平衡。
Genes Dev. 2004 Dec 1;18(23):2973-83. doi: 10.1101/gad.323004.
9
Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages.果蝇染色体JIL-1激酶等位基因的遗传和表型分析揭示了多个发育阶段的功能需求。
Genetics. 2003 Nov;165(3):1341-54. doi: 10.1093/genetics/165.3.1341.
10
Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila.位置效应斑驳与果蝇染色质调控的遗传学剖析
Semin Cell Dev Biol. 2003 Feb;14(1):67-75. doi: 10.1016/s1084-9521(02)00138-6.

JIL-1组蛋白H3S10激酶的功能缺失等位基因增强了果蝇异染色质中着丝粒周围位点的位置效应斑驳。

Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin.

作者信息

Bao Xiaomin, Deng Huai, Johansen Jørgen, Girton Jack, Johansen Kristen M

机构信息

Department of Biochemistry, Biophysics, and Molecular Biology Iowa State University Ames, Iowa 50011, USA.

出版信息

Genetics. 2007 Jun;176(2):1355-8. doi: 10.1534/genetics.107.073676. Epub 2007 Apr 15.

DOI:10.1534/genetics.107.073676
PMID:17435241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1894597/
Abstract

In this study we show that loss-of-function alleles of the JIL-1 histone H3S10 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1(Su(var)3-1[3]) allele acts as a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing.

摘要

在本研究中，我们表明，JIL-1组蛋白H3S10激酶的功能丧失等位基因在着丝粒周围位点作为位置效应斑驳的增强子，而功能获得性JIL-1(Su(var)3-1[3])等位基因作为抑制子，有力地支持了JIL-1在维持常染色质、对抗异染色质扩散和基因沉默方面的功能作用。