Lordelo Roberta A, Mancini Marcio C, Cercato Cíntia, Halpern Alfredo
Grupo de Obesidade e Síndrome Metabólica do Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo.
Arq Bras Endocrinol Metabol. 2007 Feb;51(1):34-41. doi: 10.1590/s0004-27302007000100007.
Several endocrine changes have been described in the obesity state. The corticotropic axis is hyperresponsive and there is enhancement of hormonal clearance, but cortisol levels are within the normal range. It is important to characterize a pseudo-Cushing in obesity. Leptin seems to be a permissive hormone for the beginning of puberty. In adults, gonadotropines are normal, and hyperandrogenism and hyperestrogenism are found. In women, insulin resistance has a central role in polycystic ovarian syndrome (POS), which is associated to ovarian hyperandrogenemia. In obese subjects, growth hormone (GH) is generally low and IGF1 is normal. Thyroid function is commonly normal in obese subjects.
肥胖状态下已发现多种内分泌变化。促肾上腺皮质激素轴反应过度，激素清除率增加，但皮质醇水平仍在正常范围内。明确肥胖中的假性库欣综合征很重要。瘦素似乎是青春期开始的一种允许性激素。在成年人中，促性腺激素正常，但会出现雄激素过多和雌激素过多的情况。在女性中，胰岛素抵抗在多囊卵巢综合征（PCOS）中起核心作用，该综合征与卵巢雄激素过多血症有关。在肥胖受试者中，生长激素（GH）通常较低，而胰岛素样生长因子1（IGF1）正常。肥胖受试者的甲状腺功能通常正常。
