Van Cauter E
Department of Medicine, University of Chicago, Ill.
Horm Res. 1990;34(2):45-53. doi: 10.1159/000181794.
Rapidly accumulating evidence indicates that every hypothalamo-pituitary axis is influenced by both sleep (irrespective of the time of day when it occurs) and circadian rhythmicity (irrespective of the sleep or wake condition). Circadian effects seem to be exerted by a modulation of the amplitude of secretory pulses. Sleep may affect pulse frequency. Recent studies indicate that this complex temporal organization is not limited to pituitary and pituitary-dependent hormones but also underlies glucose regulation and insulin secretion.
迅速积累的证据表明，每个下丘脑 - 垂体轴都受到睡眠（无论其发生在一天中的何时）和昼夜节律（无论睡眠或清醒状态）的影响。昼夜节律的影响似乎是通过调节分泌脉冲的幅度来实现的。睡眠可能会影响脉冲频率。最近的研究表明，这种复杂的时间组织不仅限于垂体和依赖垂体的激素，也是葡萄糖调节和胰岛素分泌的基础。
