Gillette Guyonnet S, Andrieu S, Vellas B
Service de Medecine Interne et de Gerontologie Clinique, Pavillon J.P. Junod, Centre Hospitalier Universitaire La Grave-Casselardit, Toulouse cedex 9, France.
J Nutr Health Aging. 2007 Mar-Apr;11(2):119-24.
Silica present in drinking water may be protective with respect to the decrease of cognitive function as it was suggested by several epidemiologic studies. Data from French cohort have demonstrated that aluminium in drinking water seems to have a deleterious effect and increased the risk of cognitive impairment when the silica concentrations were low. Moreover, it has been shown that the performances to a cognitive test were positively correlated to the consumption of silica and that the risk of Alzheimer's disease (AD) was reduced in subjects who had the higher daily silica intake compared to the others. The silica is probably the natural antidote of the aluminium and could play a benefit role by decreasing the biodisponibility of aluminium, whose neurotoxicity is now clearly established. Data have suggested the possible use of silicates as a therapeutic agent for AD since both model tangles and precipitated beta-pleated sheets of betaA4 can be reversed to soluble forms by silicates. The role of silica in drinking water on cognitive function has been however little studied and clear results have not yet emerge. The potential benefit of silica needs to be confirmed in additional investigations to exclude causes of error related to certain methodological biases. If such association do indeed exist, interventional strategies could be set up to reduce the incidence of AD. The aim of this paper is to review articles published on silica present in drinking water in relation with AD and associated disorders.
一些流行病学研究表明，饮用水中的二氧化硅可能对认知功能下降具有保护作用。来自法国队列的数据表明，当二氧化硅浓度较低时，饮用水中的铝似乎具有有害影响，并增加了认知障碍的风险。此外，研究表明，认知测试的表现与二氧化硅的摄入量呈正相关，与其他受试者相比，每日二氧化硅摄入量较高的受试者患阿尔茨海默病（AD）的风险降低。二氧化硅可能是铝的天然解毒剂，通过降低铝的生物利用度发挥有益作用，铝的神经毒性现已明确。数据表明，硅酸盐可能作为AD的治疗剂，因为模型缠结和βA4的沉淀β折叠片都可以被硅酸盐逆转成可溶形式。然而，饮用水中二氧化硅对认知功能的作用研究较少，尚未得出明确结果。二氧化硅的潜在益处需要在进一步的研究中得到证实，以排除与某些方法学偏差相关的误差原因。如果这种关联确实存在，可以制定干预策略以降低AD的发病率。本文的目的是综述与AD及相关疾病有关的饮用水中二氧化硅的已发表文章。
