The Birchall Centre, Lennard-Jones Laboratories, Keele University, Stoke-on-Trent, Staffordshire, UK.
J Alzheimers Dis. 2013;33(2):423-30. doi: 10.3233/JAD-2012-121231.
There has been a plausible link between human exposure to aluminum and Alzheimer's disease for several decades. We contend that the only direct and ethically acceptable experimental test of the 'aluminum hypothesis', which would provide unequivocal data specific to the link, is to test the null hypothesis that a reduction in the body burden of aluminum to its lowest practical limit would have no influence upon the incidence, progression, or severity of Alzheimer's disease. Herein we are testing the hypothesis that silicon-rich mineral waters can be used as non-invasive methods to reduce the body burden of aluminum in individuals with Alzheimer's disease and a control group consisting of their carers and partners. We have shown that drinking up to 1 L of a silicon-rich mineral water each day for 12 weeks facilitated the removal of aluminum via the urine in both patient and control groups without any concomitant affect upon the urinary excretion of the essential metals, iron and copper. We have provided preliminary evidence that over 12 weeks of silicon-rich mineral water therapy the body burden of aluminum fell in individuals with Alzheimer's disease and, concomitantly, cognitive performance showed clinically relevant improvements in at least 3 out of 15 individuals. This is a first step in a much needed rigorous test of the 'aluminum hypothesis of Alzheimer's disease' and a longer term study involving many more individuals is now warranted.
几十年来，人们一直认为人体接触铝与阿尔茨海默病之间存在合理的联系。我们认为，“铝假说”唯一直接且符合伦理的实验检验方法是检验零假设，即降低铝的体内负荷至最低实际限度，不会对阿尔茨海默病的发病率、病程进展或严重程度产生任何影响。在此，我们正在检验假设，即富含硅的矿泉水可作为非侵入性方法，降低阿尔茨海默病患者和对照组（由他们的护理人员和伴侣组成）体内的铝负荷。我们已经证明，在 12 周内每天饮用多达 1 升富含硅的矿泉水，可以促进患者和对照组的尿液排铝，而对必需金属铁和铜的尿液排泄没有任何伴随影响。我们提供了初步证据，表明在 12 周的富含硅矿泉水治疗后，阿尔茨海默病患者体内的铝负荷下降，同时，认知功能在至少 15 名患者中的 3 名中显示出具有临床意义的改善。这是对“阿尔茨海默病的铝假说”进行严格检验的重要一步，现在需要进行一项涉及更多患者的长期研究。
