Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorens 21, 43201 Reus, Catalonia, Spain.
Nutr Rev. 2011 Jan;69(1):41-51. doi: 10.1111/j.1753-4887.2010.00360.x.
Silicon is an essential element for some lower forms of life. However, it is not generally considered an essential nutrient for mammals and the mechanisms underlying its potential essentiality remain partially unknown. In recent years, a possible association between the aluminum and silicon levels in drinking water and Alzheimer's disease (AD) has been suggested. It has been reported that silicon might have a protective effect for limiting oral aluminum absorption. This review is focused primarily on the potential role of silicon in preventing oral aluminum absorption and retention in mammals. The results of a number of studies suggest that dietary silicon supplementation could be of therapeutic value for preventing chronic aluminum accumulation in the brain, and hence, be a potential therapy for AD. However, it must be noted that controversy remains about whether aluminum accumulation in the brain is a cause or a consequence of AD. It is suggested that further investigation of this issue is warranted.
硅是一些低等生命形式的必需元素。然而，一般来说，硅并不被认为是哺乳动物的必需营养素，其潜在必需性的机制仍部分未知。近年来，饮用水中铝和硅水平与阿尔茨海默病（AD）之间可能存在关联的说法已经提出。据报道，硅可能具有保护作用，可以限制口腔对铝的吸收。本综述主要关注硅在防止哺乳动物口腔铝吸收和滞留方面的潜在作用。多项研究的结果表明，膳食硅补充可能具有治疗价值，可预防大脑中慢性铝积累，因此可能是 AD 的一种潜在治疗方法。然而，必须指出的是，关于大脑中铝积累是 AD 的原因还是后果，仍然存在争议。有人建议，进一步研究这个问题是有必要的。
