Lo Yow-Jen, Sheu Ming-Thau, Tsai Wen-Chi, Lin Yun-Ho, Li Jau-Le, Liang Yu-Chih, Chang Chi-Ching, Hsieh Ming-Shium, Chen Chien-Ho
College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC.
Rheumatol Int. 2007 Oct;27(12):1099-111. doi: 10.1007/s00296-007-0346-1. Epub 2007 Apr 14.
Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E(2) (PGE(2)) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE(2, )and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.
通过定期关节内注射单独的透明质酸盐（HA组）以及低浓度或高浓度吲哚美辛（LI-HA或HI-HA组），评估透明质酸盐和吲哚美辛联合治疗抗原诱导性关节炎（AIA）兔的效果，评估指标包括关节肿胀、C反应蛋白（CRP）和前列腺素E2（PGE2）水平。终点分析包括基质金属蛋白酶-3（MMP-3）活性以及关节的宏观和组织学检查。结果表明，与HA组相比，LI-HA组和HI-HA组的治疗导致CRP、PGE2和MMP-3受到统计学上的显著抑制。仅在LI-HA组观察到血清CRP受到抑制。血清MMP-3抑制程度的顺序为LI-HA>HI-HA>HA。基于对血管翳形成、增生、炎症、关节渗漏和侵蚀以及蛋白聚糖丢失的宏观和组织学分析，与HA组相比，仅LI-HA组显示出统计学上的显著改善，与对照组相比，HI-HA组显示出统计学上的显著改善。
